Secreted HMGB1 from Wnt activated intestinal cells is required to maintain a crypt progenitor phenotype

BACKGROUND AND AIMS: Colorectal cancer (CRC) arises via multiple genetic changes. Mutation of the tumour suppressor gene APC, a key regulator of Wnt signalling, is recognised as a frequent early driving mutation in CRC. We have previously shown that conditional loss of Apc within the murine small in...

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Detalles Bibliográficos
Autores principales: Reed, Karen R., Song, Fei, Young, Maddy A., Hassan, Nurudeen, Antoine, Daniel J., Gemici, Nesibe-Princess B., Clarke, Alan R., Jenkins, John R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239505/
https://www.ncbi.nlm.nih.gov/pubmed/27323825
http://dx.doi.org/10.18632/oncotarget.10076

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