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Long non-coding RNA HULC as a novel serum biomarker for diagnosis and prognosis prediction of gastric cancer

Long non-coding RNAs (lncRNAs) have recently emerged as vital players in tumor biology with potential value in cancer diagnosis, prognosis, and therapeutics. The lncRNA HULC (highly up-regulated in liver cancer) is increased in many malignancies, yet its serum expression profile and clinical value i...

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Autores principales: Jin, Chunjing, Shi, Wei, Wang, Feng, Shen, Xianjuan, Qi, Jing, Cong, Hui, Yuan, Jie, Shi, Linying, Zhu, Bingying, Luo, Xi, Zhang, Yan, Ju, Shaoqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239513/
https://www.ncbi.nlm.nih.gov/pubmed/27322075
http://dx.doi.org/10.18632/oncotarget.10107
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author Jin, Chunjing
Shi, Wei
Wang, Feng
Shen, Xianjuan
Qi, Jing
Cong, Hui
Yuan, Jie
Shi, Linying
Zhu, Bingying
Luo, Xi
Zhang, Yan
Ju, Shaoqing
author_facet Jin, Chunjing
Shi, Wei
Wang, Feng
Shen, Xianjuan
Qi, Jing
Cong, Hui
Yuan, Jie
Shi, Linying
Zhu, Bingying
Luo, Xi
Zhang, Yan
Ju, Shaoqing
author_sort Jin, Chunjing
collection PubMed
description Long non-coding RNAs (lncRNAs) have recently emerged as vital players in tumor biology with potential value in cancer diagnosis, prognosis, and therapeutics. The lncRNA HULC (highly up-regulated in liver cancer) is increased in many malignancies, yet its serum expression profile and clinical value in gastric cancer (GC) patients remain unclear. Quantitative real-time polymerase chain reaction (RT-qPCR) for large-scale analysis of the serum expression of HULC in GC patients reliably detected circulating HULC and revealed that it is upregulated in GC patients. A high serum HULC level correlated with tumor size, lymph node metastasis, distant metastasis, tumor-node-metastasis stage, and H. pylori infection. The area under the ROC curve for HULC was up to 0.888, which was higher than that for CEA (0.694) and CA72-4 (0.514). Follow-up detection and Kaplan-Meier curve analysis revealed HULC is a good predictor of GC prognosis. Our present study indicates that circulating HULC may represent a novel serum tumor marker for early diagnosis and monitoring progression and prognosis of GC.
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spelling pubmed-52395132017-01-24 Long non-coding RNA HULC as a novel serum biomarker for diagnosis and prognosis prediction of gastric cancer Jin, Chunjing Shi, Wei Wang, Feng Shen, Xianjuan Qi, Jing Cong, Hui Yuan, Jie Shi, Linying Zhu, Bingying Luo, Xi Zhang, Yan Ju, Shaoqing Oncotarget Research Paper Long non-coding RNAs (lncRNAs) have recently emerged as vital players in tumor biology with potential value in cancer diagnosis, prognosis, and therapeutics. The lncRNA HULC (highly up-regulated in liver cancer) is increased in many malignancies, yet its serum expression profile and clinical value in gastric cancer (GC) patients remain unclear. Quantitative real-time polymerase chain reaction (RT-qPCR) for large-scale analysis of the serum expression of HULC in GC patients reliably detected circulating HULC and revealed that it is upregulated in GC patients. A high serum HULC level correlated with tumor size, lymph node metastasis, distant metastasis, tumor-node-metastasis stage, and H. pylori infection. The area under the ROC curve for HULC was up to 0.888, which was higher than that for CEA (0.694) and CA72-4 (0.514). Follow-up detection and Kaplan-Meier curve analysis revealed HULC is a good predictor of GC prognosis. Our present study indicates that circulating HULC may represent a novel serum tumor marker for early diagnosis and monitoring progression and prognosis of GC. Impact Journals LLC 2016-06-16 /pmc/articles/PMC5239513/ /pubmed/27322075 http://dx.doi.org/10.18632/oncotarget.10107 Text en Copyright: © 2016 Jin et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Jin, Chunjing
Shi, Wei
Wang, Feng
Shen, Xianjuan
Qi, Jing
Cong, Hui
Yuan, Jie
Shi, Linying
Zhu, Bingying
Luo, Xi
Zhang, Yan
Ju, Shaoqing
Long non-coding RNA HULC as a novel serum biomarker for diagnosis and prognosis prediction of gastric cancer
title Long non-coding RNA HULC as a novel serum biomarker for diagnosis and prognosis prediction of gastric cancer
title_full Long non-coding RNA HULC as a novel serum biomarker for diagnosis and prognosis prediction of gastric cancer
title_fullStr Long non-coding RNA HULC as a novel serum biomarker for diagnosis and prognosis prediction of gastric cancer
title_full_unstemmed Long non-coding RNA HULC as a novel serum biomarker for diagnosis and prognosis prediction of gastric cancer
title_short Long non-coding RNA HULC as a novel serum biomarker for diagnosis and prognosis prediction of gastric cancer
title_sort long non-coding rna hulc as a novel serum biomarker for diagnosis and prognosis prediction of gastric cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239513/
https://www.ncbi.nlm.nih.gov/pubmed/27322075
http://dx.doi.org/10.18632/oncotarget.10107
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