Inhibition of SREBP increases gefitinib sensitivity in non-small cell lung cancer cells

The clinical success of EGFR inhibitors in patients with lung cancer is limited by the inevitable development of treatment resistance. Here, we show that inhibition of SREBP increase gefitinib sensitivity in vitro and in vivo. Interference of SREBP1 binding partner MARVELD1 potentiate the therapeuti...

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Autores principales: Li, Jiajin, Yan, Hui, Zhao, Li, Jia, Wenzhi, Yang, Hao, Liu, Liu, Zhou, Xiang, Miao, Ping, Sun, Xiaoguang, Song, Shaoli, Zhao, Xiaoping, Liu, Jianjun, Huang, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239560/
https://www.ncbi.nlm.nih.gov/pubmed/27447558
http://dx.doi.org/10.18632/oncotarget.10721
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author Li, Jiajin
Yan, Hui
Zhao, Li
Jia, Wenzhi
Yang, Hao
Liu, Liu
Zhou, Xiang
Miao, Ping
Sun, Xiaoguang
Song, Shaoli
Zhao, Xiaoping
Liu, Jianjun
Huang, Gang
author_facet Li, Jiajin
Yan, Hui
Zhao, Li
Jia, Wenzhi
Yang, Hao
Liu, Liu
Zhou, Xiang
Miao, Ping
Sun, Xiaoguang
Song, Shaoli
Zhao, Xiaoping
Liu, Jianjun
Huang, Gang
author_sort Li, Jiajin
collection PubMed
description The clinical success of EGFR inhibitors in patients with lung cancer is limited by the inevitable development of treatment resistance. Here, we show that inhibition of SREBP increase gefitinib sensitivity in vitro and in vivo. Interference of SREBP1 binding partner MARVELD1 potentiate the therapeutic effect of gefitinib as well. Mechanistically, SREBP inhibition decreases the cell membrane fluidity, results in a decreased tyrosine phosphorylation of EGFR. Therefore, targeting lipid metabolism combined with EGFR-TKIs is potentially a novel therapeutic strategies for cancer treatment.
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spelling pubmed-52395602017-01-24 Inhibition of SREBP increases gefitinib sensitivity in non-small cell lung cancer cells Li, Jiajin Yan, Hui Zhao, Li Jia, Wenzhi Yang, Hao Liu, Liu Zhou, Xiang Miao, Ping Sun, Xiaoguang Song, Shaoli Zhao, Xiaoping Liu, Jianjun Huang, Gang Oncotarget Research Paper The clinical success of EGFR inhibitors in patients with lung cancer is limited by the inevitable development of treatment resistance. Here, we show that inhibition of SREBP increase gefitinib sensitivity in vitro and in vivo. Interference of SREBP1 binding partner MARVELD1 potentiate the therapeutic effect of gefitinib as well. Mechanistically, SREBP inhibition decreases the cell membrane fluidity, results in a decreased tyrosine phosphorylation of EGFR. Therefore, targeting lipid metabolism combined with EGFR-TKIs is potentially a novel therapeutic strategies for cancer treatment. Impact Journals LLC 2016-07-20 /pmc/articles/PMC5239560/ /pubmed/27447558 http://dx.doi.org/10.18632/oncotarget.10721 Text en Copyright: © 2016 Li et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Li, Jiajin
Yan, Hui
Zhao, Li
Jia, Wenzhi
Yang, Hao
Liu, Liu
Zhou, Xiang
Miao, Ping
Sun, Xiaoguang
Song, Shaoli
Zhao, Xiaoping
Liu, Jianjun
Huang, Gang
Inhibition of SREBP increases gefitinib sensitivity in non-small cell lung cancer cells
title Inhibition of SREBP increases gefitinib sensitivity in non-small cell lung cancer cells
title_full Inhibition of SREBP increases gefitinib sensitivity in non-small cell lung cancer cells
title_fullStr Inhibition of SREBP increases gefitinib sensitivity in non-small cell lung cancer cells
title_full_unstemmed Inhibition of SREBP increases gefitinib sensitivity in non-small cell lung cancer cells
title_short Inhibition of SREBP increases gefitinib sensitivity in non-small cell lung cancer cells
title_sort inhibition of srebp increases gefitinib sensitivity in non-small cell lung cancer cells
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239560/
https://www.ncbi.nlm.nih.gov/pubmed/27447558
http://dx.doi.org/10.18632/oncotarget.10721
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