Cargando…
Inhibition of SREBP increases gefitinib sensitivity in non-small cell lung cancer cells
The clinical success of EGFR inhibitors in patients with lung cancer is limited by the inevitable development of treatment resistance. Here, we show that inhibition of SREBP increase gefitinib sensitivity in vitro and in vivo. Interference of SREBP1 binding partner MARVELD1 potentiate the therapeuti...
Autores principales: | Li, Jiajin, Yan, Hui, Zhao, Li, Jia, Wenzhi, Yang, Hao, Liu, Liu, Zhou, Xiang, Miao, Ping, Sun, Xiaoguang, Song, Shaoli, Zhao, Xiaoping, Liu, Jianjun, Huang, Gang |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239560/ https://www.ncbi.nlm.nih.gov/pubmed/27447558 http://dx.doi.org/10.18632/oncotarget.10721 |
Ejemplares similares
-
Inhibition of Lipolysis by Mercaptoacetate and Etomoxir Specifically Sensitize Drug-Resistant Lung Adenocarcinoma Cell to Paclitaxel
por: Li, Jiajin, et al.
Publicado: (2013) -
Dichloroacetate restores drug sensitivity in paclitaxel-resistant cells by inducing citric acid accumulation
por: Zhou, Xiang, et al.
Publicado: (2015) -
Increased glutamine anabolism sensitizes non-small cell lung cancer to gefitinib treatment
por: Wang, Liang, et al.
Publicado: (2018) -
PRMT5 competitively binds to CDK4 to promote G1-S transition upon glucose induction in hepatocellular carcinoma
por: Yang, Hao, et al.
Publicado: (2016) -
Glycerol kinase 5 confers gefitinib resistance through SREBP1/SCD1 signaling pathway
por: Zhou, Jian, et al.
Publicado: (2019)