Cargando…

Association between the APEX1 Asp148Glu polymorphism and prostate cancer, especially among Asians: a new evidence-based analysis

BACKGROUND: Prostate cancer (Pca) is a serious disease associated with considerable morbidity and mortality. As a causative factor, the Asp148Glu polymorphism has been identified in the apurinic/apyrimidinic endonuclease (APEX1) gene. However, the association among Asians is considered controversial...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Yang, Li, Jie, Mo, Zengnan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239571/
https://www.ncbi.nlm.nih.gov/pubmed/27248666
http://dx.doi.org/10.18632/oncotarget.9693
_version_ 1782495922733711360
author Chen, Yang
Li, Jie
Mo, Zengnan
author_facet Chen, Yang
Li, Jie
Mo, Zengnan
author_sort Chen, Yang
collection PubMed
description BACKGROUND: Prostate cancer (Pca) is a serious disease associated with considerable morbidity and mortality. As a causative factor, the Asp148Glu polymorphism has been identified in the apurinic/apyrimidinic endonuclease (APEX1) gene. However, the association among Asians is considered controversial. METHODS: Evidence for this association was obtained from the PubMed, Embase, HuGENet and Chinese National Knowledge Infrastructure (CNKI) databases. In the analysis, four models were applied. Associations between the APEX1 polymorphism and the invasiveness of Pca based on the Gleason score, prostate-specific antigen expression and clinical status were also evaluated. RESULTS: Seven articles were included in the analysis. Positive results were not only discovered in the pooled analysis, but also among patients of mixed descentand Asian descent. However, after considering the Hardy-Weinberg equilibrium (HWE), we observed only a 1.557-fold increase in Pca risk for subjects of Asian descent(GG vs. TT: OR=1.557, 95%CI=1.069-2.268) under the co-dominant model. Additionally, we did not also find any relationship between the APEX1 Asp148Glu polymorphism and invasive Pca risk. CONCLUSION: On the basis of the function of the APEX1 Asp148Glu polymorphism, recent studies, and our results, we suggest that the APEX1 Asp148Glu polymorphism might be important in stimulating the development of Pca rather than its invasiveness in various populations, especially for Asians.
format Online
Article
Text
id pubmed-5239571
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-52395712017-01-24 Association between the APEX1 Asp148Glu polymorphism and prostate cancer, especially among Asians: a new evidence-based analysis Chen, Yang Li, Jie Mo, Zengnan Oncotarget Review BACKGROUND: Prostate cancer (Pca) is a serious disease associated with considerable morbidity and mortality. As a causative factor, the Asp148Glu polymorphism has been identified in the apurinic/apyrimidinic endonuclease (APEX1) gene. However, the association among Asians is considered controversial. METHODS: Evidence for this association was obtained from the PubMed, Embase, HuGENet and Chinese National Knowledge Infrastructure (CNKI) databases. In the analysis, four models were applied. Associations between the APEX1 polymorphism and the invasiveness of Pca based on the Gleason score, prostate-specific antigen expression and clinical status were also evaluated. RESULTS: Seven articles were included in the analysis. Positive results were not only discovered in the pooled analysis, but also among patients of mixed descentand Asian descent. However, after considering the Hardy-Weinberg equilibrium (HWE), we observed only a 1.557-fold increase in Pca risk for subjects of Asian descent(GG vs. TT: OR=1.557, 95%CI=1.069-2.268) under the co-dominant model. Additionally, we did not also find any relationship between the APEX1 Asp148Glu polymorphism and invasive Pca risk. CONCLUSION: On the basis of the function of the APEX1 Asp148Glu polymorphism, recent studies, and our results, we suggest that the APEX1 Asp148Glu polymorphism might be important in stimulating the development of Pca rather than its invasiveness in various populations, especially for Asians. Impact Journals LLC 2016-05-29 /pmc/articles/PMC5239571/ /pubmed/27248666 http://dx.doi.org/10.18632/oncotarget.9693 Text en Copyright: © 2016 Chen et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Chen, Yang
Li, Jie
Mo, Zengnan
Association between the APEX1 Asp148Glu polymorphism and prostate cancer, especially among Asians: a new evidence-based analysis
title Association between the APEX1 Asp148Glu polymorphism and prostate cancer, especially among Asians: a new evidence-based analysis
title_full Association between the APEX1 Asp148Glu polymorphism and prostate cancer, especially among Asians: a new evidence-based analysis
title_fullStr Association between the APEX1 Asp148Glu polymorphism and prostate cancer, especially among Asians: a new evidence-based analysis
title_full_unstemmed Association between the APEX1 Asp148Glu polymorphism and prostate cancer, especially among Asians: a new evidence-based analysis
title_short Association between the APEX1 Asp148Glu polymorphism and prostate cancer, especially among Asians: a new evidence-based analysis
title_sort association between the apex1 asp148glu polymorphism and prostate cancer, especially among asians: a new evidence-based analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239571/
https://www.ncbi.nlm.nih.gov/pubmed/27248666
http://dx.doi.org/10.18632/oncotarget.9693
work_keys_str_mv AT chenyang associationbetweentheapex1asp148glupolymorphismandprostatecancerespeciallyamongasiansanewevidencebasedanalysis
AT lijie associationbetweentheapex1asp148glupolymorphismandprostatecancerespeciallyamongasiansanewevidencebasedanalysis
AT mozengnan associationbetweentheapex1asp148glupolymorphismandprostatecancerespeciallyamongasiansanewevidencebasedanalysis