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MiR-222 in Cardiovascular Diseases: Physiology and Pathology
MicroRNAs (miRNAs and miRs) are endogenous 19–22 nucleotide, small noncoding RNAs with highly conservative and tissue specific expression. They can negatively modulate target gene expressions through decreasing transcription or posttranscriptional inducing mRNA decay. Increasing evidence suggests th...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239839/ https://www.ncbi.nlm.nih.gov/pubmed/28127557 http://dx.doi.org/10.1155/2017/4962426 |
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author | Ding, Shengguang Huang, Haitao Xu, Yiming Zhu, Hao Zhong, Chongjun |
author_facet | Ding, Shengguang Huang, Haitao Xu, Yiming Zhu, Hao Zhong, Chongjun |
author_sort | Ding, Shengguang |
collection | PubMed |
description | MicroRNAs (miRNAs and miRs) are endogenous 19–22 nucleotide, small noncoding RNAs with highly conservative and tissue specific expression. They can negatively modulate target gene expressions through decreasing transcription or posttranscriptional inducing mRNA decay. Increasing evidence suggests that deregulated miRNAs play an important role in the genesis of cardiovascular diseases. Additionally, circulating miRNAs can be biomarkers for cardiovascular diseases. MiR-222 has been reported to play important roles in a variety of physiological and pathological processes in the heart. Here we reviewed the recent studies about the roles of miR-222 in cardiovascular diseases. MiR-222 may be a potential cardiovascular biomarker and a new therapeutic target in cardiovascular diseases. |
format | Online Article Text |
id | pubmed-5239839 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-52398392017-01-26 MiR-222 in Cardiovascular Diseases: Physiology and Pathology Ding, Shengguang Huang, Haitao Xu, Yiming Zhu, Hao Zhong, Chongjun Biomed Res Int Review Article MicroRNAs (miRNAs and miRs) are endogenous 19–22 nucleotide, small noncoding RNAs with highly conservative and tissue specific expression. They can negatively modulate target gene expressions through decreasing transcription or posttranscriptional inducing mRNA decay. Increasing evidence suggests that deregulated miRNAs play an important role in the genesis of cardiovascular diseases. Additionally, circulating miRNAs can be biomarkers for cardiovascular diseases. MiR-222 has been reported to play important roles in a variety of physiological and pathological processes in the heart. Here we reviewed the recent studies about the roles of miR-222 in cardiovascular diseases. MiR-222 may be a potential cardiovascular biomarker and a new therapeutic target in cardiovascular diseases. Hindawi Publishing Corporation 2017 2017-01-03 /pmc/articles/PMC5239839/ /pubmed/28127557 http://dx.doi.org/10.1155/2017/4962426 Text en Copyright © 2017 Shengguang Ding et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Ding, Shengguang Huang, Haitao Xu, Yiming Zhu, Hao Zhong, Chongjun MiR-222 in Cardiovascular Diseases: Physiology and Pathology |
title | MiR-222 in Cardiovascular Diseases: Physiology and Pathology |
title_full | MiR-222 in Cardiovascular Diseases: Physiology and Pathology |
title_fullStr | MiR-222 in Cardiovascular Diseases: Physiology and Pathology |
title_full_unstemmed | MiR-222 in Cardiovascular Diseases: Physiology and Pathology |
title_short | MiR-222 in Cardiovascular Diseases: Physiology and Pathology |
title_sort | mir-222 in cardiovascular diseases: physiology and pathology |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239839/ https://www.ncbi.nlm.nih.gov/pubmed/28127557 http://dx.doi.org/10.1155/2017/4962426 |
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