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Amyloid β Peptide-Induced Changes in Prefrontal Cortex Activity and Its Response to Hippocampal Input

Alterations in prefrontal cortex (PFC) function and abnormalities in its interactions with other brain areas (i.e., the hippocampus) have been related to Alzheimer Disease (AD). Considering that these malfunctions correlate with the increase in the brain's amyloid beta (Aβ) peptide production,...

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Autores principales: Flores-Martínez, Ernesto, Peña-Ortega, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239987/
https://www.ncbi.nlm.nih.gov/pubmed/28127312
http://dx.doi.org/10.1155/2017/7386809
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author Flores-Martínez, Ernesto
Peña-Ortega, Fernando
author_facet Flores-Martínez, Ernesto
Peña-Ortega, Fernando
author_sort Flores-Martínez, Ernesto
collection PubMed
description Alterations in prefrontal cortex (PFC) function and abnormalities in its interactions with other brain areas (i.e., the hippocampus) have been related to Alzheimer Disease (AD). Considering that these malfunctions correlate with the increase in the brain's amyloid beta (Aβ) peptide production, here we looked for a causal relationship between these pathognomonic signs of AD. Thus, we tested whether or not Aβ affects the activity of the PFC network and the activation of this cortex by hippocampal input stimulation in vitro. We found that Aβ application to brain slices inhibits PFC spontaneous network activity as well as PFC activation, both at the population and at the single-cell level, when the hippocampal input is stimulated. Our data suggest that Aβ can contribute to AD by disrupting PFC activity and its long-range interactions throughout the brain.
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spelling pubmed-52399872017-01-26 Amyloid β Peptide-Induced Changes in Prefrontal Cortex Activity and Its Response to Hippocampal Input Flores-Martínez, Ernesto Peña-Ortega, Fernando Int J Pept Research Article Alterations in prefrontal cortex (PFC) function and abnormalities in its interactions with other brain areas (i.e., the hippocampus) have been related to Alzheimer Disease (AD). Considering that these malfunctions correlate with the increase in the brain's amyloid beta (Aβ) peptide production, here we looked for a causal relationship between these pathognomonic signs of AD. Thus, we tested whether or not Aβ affects the activity of the PFC network and the activation of this cortex by hippocampal input stimulation in vitro. We found that Aβ application to brain slices inhibits PFC spontaneous network activity as well as PFC activation, both at the population and at the single-cell level, when the hippocampal input is stimulated. Our data suggest that Aβ can contribute to AD by disrupting PFC activity and its long-range interactions throughout the brain. Hindawi Publishing Corporation 2017 2017-01-03 /pmc/articles/PMC5239987/ /pubmed/28127312 http://dx.doi.org/10.1155/2017/7386809 Text en Copyright © 2017 E. Flores-Martínez and F. Peña-Ortega. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Flores-Martínez, Ernesto
Peña-Ortega, Fernando
Amyloid β Peptide-Induced Changes in Prefrontal Cortex Activity and Its Response to Hippocampal Input
title Amyloid β Peptide-Induced Changes in Prefrontal Cortex Activity and Its Response to Hippocampal Input
title_full Amyloid β Peptide-Induced Changes in Prefrontal Cortex Activity and Its Response to Hippocampal Input
title_fullStr Amyloid β Peptide-Induced Changes in Prefrontal Cortex Activity and Its Response to Hippocampal Input
title_full_unstemmed Amyloid β Peptide-Induced Changes in Prefrontal Cortex Activity and Its Response to Hippocampal Input
title_short Amyloid β Peptide-Induced Changes in Prefrontal Cortex Activity and Its Response to Hippocampal Input
title_sort amyloid β peptide-induced changes in prefrontal cortex activity and its response to hippocampal input
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239987/
https://www.ncbi.nlm.nih.gov/pubmed/28127312
http://dx.doi.org/10.1155/2017/7386809
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