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Early-life adversity accelerates cellular ageing and affects adult inflammation: Experimental evidence from the European starling
Early-life adversity is associated with accelerated cellular ageing during development and increased inflammation during adulthood. However, human studies can only establish correlation, not causation, and existing experimental animal approaches alter multiple components of early-life adversity simu...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240102/ https://www.ncbi.nlm.nih.gov/pubmed/28094324 http://dx.doi.org/10.1038/srep40794 |
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author | Nettle, Daniel Andrews, Clare Reichert, Sophie Bedford, Tom Kolenda, Claire Parker, Craig Martin-Ruiz, Carmen Monaghan, Pat Bateson, Melissa |
author_facet | Nettle, Daniel Andrews, Clare Reichert, Sophie Bedford, Tom Kolenda, Claire Parker, Craig Martin-Ruiz, Carmen Monaghan, Pat Bateson, Melissa |
author_sort | Nettle, Daniel |
collection | PubMed |
description | Early-life adversity is associated with accelerated cellular ageing during development and increased inflammation during adulthood. However, human studies can only establish correlation, not causation, and existing experimental animal approaches alter multiple components of early-life adversity simultaneously. We developed a novel hand-rearing paradigm in European starling nestlings (Sturnus vulgaris), in which we separately manipulated nutritional shortfall and begging effort for a period of 10 days. The experimental treatments accelerated erythrocyte telomere attrition and increased DNA damage measured in the juvenile period. For telomere attrition, amount of food and begging effort exerted additive effects. Only the combination of low food amount and high begging effort increased DNA damage. We then measured two markers of inflammation, high-sensitivity C-reactive protein and interleukin-6, when the birds were adults. The experimental treatments affected both inflammatory markers, though the patterns were complex and different for each marker. The effect of the experimental treatments on adult interleukin-6 was partially mediated by increased juvenile DNA damage. Our results show that both nutritional input and begging effort in the nestling period affect cellular ageing and adult inflammation in the starling. However, the pattern of effects is different for different biomarkers measured at different time points. |
format | Online Article Text |
id | pubmed-5240102 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-52401022017-01-23 Early-life adversity accelerates cellular ageing and affects adult inflammation: Experimental evidence from the European starling Nettle, Daniel Andrews, Clare Reichert, Sophie Bedford, Tom Kolenda, Claire Parker, Craig Martin-Ruiz, Carmen Monaghan, Pat Bateson, Melissa Sci Rep Article Early-life adversity is associated with accelerated cellular ageing during development and increased inflammation during adulthood. However, human studies can only establish correlation, not causation, and existing experimental animal approaches alter multiple components of early-life adversity simultaneously. We developed a novel hand-rearing paradigm in European starling nestlings (Sturnus vulgaris), in which we separately manipulated nutritional shortfall and begging effort for a period of 10 days. The experimental treatments accelerated erythrocyte telomere attrition and increased DNA damage measured in the juvenile period. For telomere attrition, amount of food and begging effort exerted additive effects. Only the combination of low food amount and high begging effort increased DNA damage. We then measured two markers of inflammation, high-sensitivity C-reactive protein and interleukin-6, when the birds were adults. The experimental treatments affected both inflammatory markers, though the patterns were complex and different for each marker. The effect of the experimental treatments on adult interleukin-6 was partially mediated by increased juvenile DNA damage. Our results show that both nutritional input and begging effort in the nestling period affect cellular ageing and adult inflammation in the starling. However, the pattern of effects is different for different biomarkers measured at different time points. Nature Publishing Group 2017-01-17 /pmc/articles/PMC5240102/ /pubmed/28094324 http://dx.doi.org/10.1038/srep40794 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Nettle, Daniel Andrews, Clare Reichert, Sophie Bedford, Tom Kolenda, Claire Parker, Craig Martin-Ruiz, Carmen Monaghan, Pat Bateson, Melissa Early-life adversity accelerates cellular ageing and affects adult inflammation: Experimental evidence from the European starling |
title | Early-life adversity accelerates cellular ageing and affects adult inflammation: Experimental evidence from the European starling |
title_full | Early-life adversity accelerates cellular ageing and affects adult inflammation: Experimental evidence from the European starling |
title_fullStr | Early-life adversity accelerates cellular ageing and affects adult inflammation: Experimental evidence from the European starling |
title_full_unstemmed | Early-life adversity accelerates cellular ageing and affects adult inflammation: Experimental evidence from the European starling |
title_short | Early-life adversity accelerates cellular ageing and affects adult inflammation: Experimental evidence from the European starling |
title_sort | early-life adversity accelerates cellular ageing and affects adult inflammation: experimental evidence from the european starling |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240102/ https://www.ncbi.nlm.nih.gov/pubmed/28094324 http://dx.doi.org/10.1038/srep40794 |
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