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Potassium channels of T lymphocytes take center stage in the fight against cancer

A recent study by Eil at al. published in Nature in September 2016 provides evidence that alterations of the K(+) homeostasis of tumor infiltrating lymphocytes (TILs) in necrotic areas of the tumor microenvironment (TME) suppress the function of effector T cells. Furthermore, they establish that ove...

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Detalles Bibliográficos
Autor principal: Conforti, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240326/
https://www.ncbi.nlm.nih.gov/pubmed/28105369
http://dx.doi.org/10.1186/s40425-016-0202-5
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author Conforti, Laura
author_facet Conforti, Laura
author_sort Conforti, Laura
collection PubMed
description A recent study by Eil at al. published in Nature in September 2016 provides evidence that alterations of the K(+) homeostasis of tumor infiltrating lymphocytes (TILs) in necrotic areas of the tumor microenvironment (TME) suppress the function of effector T cells. Furthermore, they establish that overexpression of K(+) channels in T lymphocytes counterbalances this negative effect of the TME and restores the ability of TILs to function, ultimately leading to increased survival of tumor bearing mice. Thus, K(+) channels in T lymphocytes become interesting new targets for novel immunotherapies in cancer. This Commentary discusses Eil’s finding in the context of the central role that K(+) channels play in the suppressed state of TILs as they mediate the immunosuppressive effects of multiple conditions of the TME including hypoxia and adenosine.
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spelling pubmed-52403262017-01-19 Potassium channels of T lymphocytes take center stage in the fight against cancer Conforti, Laura J Immunother Cancer Commentary A recent study by Eil at al. published in Nature in September 2016 provides evidence that alterations of the K(+) homeostasis of tumor infiltrating lymphocytes (TILs) in necrotic areas of the tumor microenvironment (TME) suppress the function of effector T cells. Furthermore, they establish that overexpression of K(+) channels in T lymphocytes counterbalances this negative effect of the TME and restores the ability of TILs to function, ultimately leading to increased survival of tumor bearing mice. Thus, K(+) channels in T lymphocytes become interesting new targets for novel immunotherapies in cancer. This Commentary discusses Eil’s finding in the context of the central role that K(+) channels play in the suppressed state of TILs as they mediate the immunosuppressive effects of multiple conditions of the TME including hypoxia and adenosine. BioMed Central 2017-01-17 /pmc/articles/PMC5240326/ /pubmed/28105369 http://dx.doi.org/10.1186/s40425-016-0202-5 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Conforti, Laura
Potassium channels of T lymphocytes take center stage in the fight against cancer
title Potassium channels of T lymphocytes take center stage in the fight against cancer
title_full Potassium channels of T lymphocytes take center stage in the fight against cancer
title_fullStr Potassium channels of T lymphocytes take center stage in the fight against cancer
title_full_unstemmed Potassium channels of T lymphocytes take center stage in the fight against cancer
title_short Potassium channels of T lymphocytes take center stage in the fight against cancer
title_sort potassium channels of t lymphocytes take center stage in the fight against cancer
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240326/
https://www.ncbi.nlm.nih.gov/pubmed/28105369
http://dx.doi.org/10.1186/s40425-016-0202-5
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