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Design and Methods of the Mood Disorder Cohort Research Consortium (MDCRC) Study

The Mood Disorder Cohort Research Consortium (MDCRC) study is designed as a naturalistic observational prospective cohort study for early-onset mood disorders (major depressive disorders, bipolar disorders type 1 and 2) in South Korea. The study subjects consist of two populations: 1) patients with...

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Autores principales: Cho, Chul-Hyun, Ahn, Yong-Min, Kim, Se Joo, Ha, Tae Hyun, Jeon, Hong Jin, Cha, Boseok, Moon, Eunsoo, Park, Dong Yeon, Baek, Ji Hyun, Kang, Hee-Ju, Ryu, Vin, An, Hyonggin, Lee, Heon-Jeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neuropsychiatric Association 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240466/
https://www.ncbi.nlm.nih.gov/pubmed/28096882
http://dx.doi.org/10.4306/pi.2017.14.1.100
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author Cho, Chul-Hyun
Ahn, Yong-Min
Kim, Se Joo
Ha, Tae Hyun
Jeon, Hong Jin
Cha, Boseok
Moon, Eunsoo
Park, Dong Yeon
Baek, Ji Hyun
Kang, Hee-Ju
Ryu, Vin
An, Hyonggin
Lee, Heon-Jeong
author_facet Cho, Chul-Hyun
Ahn, Yong-Min
Kim, Se Joo
Ha, Tae Hyun
Jeon, Hong Jin
Cha, Boseok
Moon, Eunsoo
Park, Dong Yeon
Baek, Ji Hyun
Kang, Hee-Ju
Ryu, Vin
An, Hyonggin
Lee, Heon-Jeong
author_sort Cho, Chul-Hyun
collection PubMed
description The Mood Disorder Cohort Research Consortium (MDCRC) study is designed as a naturalistic observational prospective cohort study for early-onset mood disorders (major depressive disorders, bipolar disorders type 1 and 2) in South Korea. The study subjects consist of two populations: 1) patients with mood disorders under 25 years old and 2) patients with mood disorders within 2 years of treatment under 35 years old. After successful screening, the subjects are evaluated using baseline assessments and serial follow-up assessments at 3-month intervals. Between the follow-up assessments, subjects are dictated to check their own daily mood status before bedtime using the eMood chart application or a paper mood diary. At the regular visits every 3 months, inter-visit assessments are evaluated based on daily mood charts and interviews with patients. In addition to the daily mood chart, sleep quality, inter-visit major and minor mood episodes, stressful life events, and medical usage pattern with medical expenses are also assessed. Genomic DNA from blood is obtained for genomic analyses. From the MDCRC study, the clinical course, prognosis, and related factors of early-onset mood disorders can be clarified. The MDCRC is also able to facilitate translational research for mood disorders and provide a resource for the convergence study of mood disorders.
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spelling pubmed-52404662017-01-17 Design and Methods of the Mood Disorder Cohort Research Consortium (MDCRC) Study Cho, Chul-Hyun Ahn, Yong-Min Kim, Se Joo Ha, Tae Hyun Jeon, Hong Jin Cha, Boseok Moon, Eunsoo Park, Dong Yeon Baek, Ji Hyun Kang, Hee-Ju Ryu, Vin An, Hyonggin Lee, Heon-Jeong Psychiatry Investig Study Protocol The Mood Disorder Cohort Research Consortium (MDCRC) study is designed as a naturalistic observational prospective cohort study for early-onset mood disorders (major depressive disorders, bipolar disorders type 1 and 2) in South Korea. The study subjects consist of two populations: 1) patients with mood disorders under 25 years old and 2) patients with mood disorders within 2 years of treatment under 35 years old. After successful screening, the subjects are evaluated using baseline assessments and serial follow-up assessments at 3-month intervals. Between the follow-up assessments, subjects are dictated to check their own daily mood status before bedtime using the eMood chart application or a paper mood diary. At the regular visits every 3 months, inter-visit assessments are evaluated based on daily mood charts and interviews with patients. In addition to the daily mood chart, sleep quality, inter-visit major and minor mood episodes, stressful life events, and medical usage pattern with medical expenses are also assessed. Genomic DNA from blood is obtained for genomic analyses. From the MDCRC study, the clinical course, prognosis, and related factors of early-onset mood disorders can be clarified. The MDCRC is also able to facilitate translational research for mood disorders and provide a resource for the convergence study of mood disorders. Korean Neuropsychiatric Association 2017-01 2016-12-29 /pmc/articles/PMC5240466/ /pubmed/28096882 http://dx.doi.org/10.4306/pi.2017.14.1.100 Text en Copyright © 2017 Korean Neuropsychiatric Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Study Protocol
Cho, Chul-Hyun
Ahn, Yong-Min
Kim, Se Joo
Ha, Tae Hyun
Jeon, Hong Jin
Cha, Boseok
Moon, Eunsoo
Park, Dong Yeon
Baek, Ji Hyun
Kang, Hee-Ju
Ryu, Vin
An, Hyonggin
Lee, Heon-Jeong
Design and Methods of the Mood Disorder Cohort Research Consortium (MDCRC) Study
title Design and Methods of the Mood Disorder Cohort Research Consortium (MDCRC) Study
title_full Design and Methods of the Mood Disorder Cohort Research Consortium (MDCRC) Study
title_fullStr Design and Methods of the Mood Disorder Cohort Research Consortium (MDCRC) Study
title_full_unstemmed Design and Methods of the Mood Disorder Cohort Research Consortium (MDCRC) Study
title_short Design and Methods of the Mood Disorder Cohort Research Consortium (MDCRC) Study
title_sort design and methods of the mood disorder cohort research consortium (mdcrc) study
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240466/
https://www.ncbi.nlm.nih.gov/pubmed/28096882
http://dx.doi.org/10.4306/pi.2017.14.1.100
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