Adipocyte Fatty Acid Binding Protein Potentiates Toxic Lipids-Induced Endoplasmic Reticulum Stress in Macrophages via Inhibition of Janus Kinase 2-dependent Autophagy

Lipotoxicity is implicated in the pathogenesis of obesity-related inflammatory complications by promoting macrophage infiltration and activation. Endoplasmic reticulum (ER) stress and adipocyte fatty acid binding protein (A-FABP) play key roles in obesity and mediate inflammatory activity through si...

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Detalles Bibliográficos
Autores principales: Hoo, Ruby L. C., Shu, Lingling, Cheng, Kenneth K. Y., Wu, Xiaoping, Liao, Boya, Wu, Donghai, Zhou, Zhiguang, Xu, Aimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240568/
https://www.ncbi.nlm.nih.gov/pubmed/28094778
http://dx.doi.org/10.1038/srep40657

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