Loss-of-function screens of druggable targetome against cancer stem–like cells

Cancer stem–like cells (CSLCs) contribute to the initiation and recurrence of tumors and to their resistance to conventional therapies. In this study, small interfering RNA (siRNA)-based screening of ∼4800 druggable genes in 3-dimensional CSLC cultures in comparison to 2-dimensional bulk cultures of...

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Detalles Bibliográficos
Autores principales: Song, Mee, Lee, Hani, Nam, Myung-Hee, Jeong, Euna, Kim, Somin, Hong, Yourae, Kim, Nayoung, Yim, Hwa Young, Yoo, Young-Ji, Kim, Jung Seok, Kim, Jin-Seok, Cho, Yong-Yeon, Mills, Gordon B., Kim, Woo-Young, Yoon, Sukjoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240669/
https://www.ncbi.nlm.nih.gov/pubmed/27811063
http://dx.doi.org/10.1096/fj.201600953

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