Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology

N-methyl-D-aspartate receptors (NMDARs), ligand-gated ionotropic glutamate receptors, play key roles in normal brain development and various neurological disorders. Here we use standing variation data from the human population to assess which protein domains within NMDAR GluN1, GluN2A and GluN2B sub...

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Detalles Bibliográficos
Autores principales: Ogden, Kevin K., Chen, Wenjuan, Swanger, Sharon A., McDaniel, Miranda J., Fan, Linlin Z., Hu, Chun, Tankovic, Anel, Kusumoto, Hirofumi, Kosobucki, Gabrielle J., Schulien, Anthony J., Su, Zhuocheng, Pecha, Joseph, Bhattacharya, Subhrajit, Petrovski, Slavé, Cohen, Adam E., Aizenman, Elias, Traynelis, Stephen F., Yuan, Hongjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240934/
https://www.ncbi.nlm.nih.gov/pubmed/28095420
http://dx.doi.org/10.1371/journal.pgen.1006536

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