Cytosolic RNA:DNA Duplexes Generated by Endogenous Reverse Transcriptase Activity as Autonomous Inducers of Skin Inflammation in Psoriasis

Psoriasis is a chronic skin disease of unknown ætiology. Recent studies suggested that a large amount of cytosolic DNA (cyDNA) in keratinocytes is breaking keratinocytes DNA tolerance and promotes self-sustained inflammation in the psoriatic lesion. We investigated the origin of this cyDNA. We show...

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Detalles Bibliográficos
Autores principales: Molès, Jean-Pierre, Griez, Anthony, Guilhou, Jean-Jacques, Girard, Céline, Nagot, Nicolas, Van de Perre, Philippe, Dujols, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240966/
https://www.ncbi.nlm.nih.gov/pubmed/28095445
http://dx.doi.org/10.1371/journal.pone.0169879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240966/
https://www.ncbi.nlm.nih.gov/pubmed/28095445
http://dx.doi.org/10.1371/journal.pone.0169879

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