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Preparing the lethal hit: interplay between exo- and endocytic pathways in cytotoxic T lymphocytes

Cytotoxic T lymphocytes patrol our body in search for infected cells which they kill through the release of cytotoxic substances contained in cytotoxic granules. The fusion of cytotoxic granules occurs at a specially formed contact site, the immunological synapse, and is tightly controlled to ensure...

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Autores principales: Chang, Hsin-Fang, Bzeih, Hawraa, Chitirala, Praneeth, Ravichandran, Keerthana, Sleiman, Marwa, Krause, Elmar, Hahn, Ulrike, Pattu, Varsha, Rettig, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241346/
https://www.ncbi.nlm.nih.gov/pubmed/27585956
http://dx.doi.org/10.1007/s00018-016-2350-7
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author Chang, Hsin-Fang
Bzeih, Hawraa
Chitirala, Praneeth
Ravichandran, Keerthana
Sleiman, Marwa
Krause, Elmar
Hahn, Ulrike
Pattu, Varsha
Rettig, Jens
author_facet Chang, Hsin-Fang
Bzeih, Hawraa
Chitirala, Praneeth
Ravichandran, Keerthana
Sleiman, Marwa
Krause, Elmar
Hahn, Ulrike
Pattu, Varsha
Rettig, Jens
author_sort Chang, Hsin-Fang
collection PubMed
description Cytotoxic T lymphocytes patrol our body in search for infected cells which they kill through the release of cytotoxic substances contained in cytotoxic granules. The fusion of cytotoxic granules occurs at a specially formed contact site, the immunological synapse, and is tightly controlled to ensure specificity. In this review, we discuss the contribution of two intracellular compartments, endosomes and cytotoxic granules, to the formation, function and disassembly of the immunological synapse. We highlight a recently proposed sequential process of fusion events at the IS upon target cell recognition. First, recycling endosomes fuse with the plasma membrane to deliver cargo required for the docking of cytotoxic granules. Second, cytotoxic granules arrive and fuse upon docking in a SNARE-dependent manner. Following fusion, membrane components of the cytotoxic granule are retrieved through endocytosis to ensure the fast, efficient serial killing of target cells that is characteristic of cytotoxic T lymphocytes.
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spelling pubmed-52413462017-02-01 Preparing the lethal hit: interplay between exo- and endocytic pathways in cytotoxic T lymphocytes Chang, Hsin-Fang Bzeih, Hawraa Chitirala, Praneeth Ravichandran, Keerthana Sleiman, Marwa Krause, Elmar Hahn, Ulrike Pattu, Varsha Rettig, Jens Cell Mol Life Sci Review Cytotoxic T lymphocytes patrol our body in search for infected cells which they kill through the release of cytotoxic substances contained in cytotoxic granules. The fusion of cytotoxic granules occurs at a specially formed contact site, the immunological synapse, and is tightly controlled to ensure specificity. In this review, we discuss the contribution of two intracellular compartments, endosomes and cytotoxic granules, to the formation, function and disassembly of the immunological synapse. We highlight a recently proposed sequential process of fusion events at the IS upon target cell recognition. First, recycling endosomes fuse with the plasma membrane to deliver cargo required for the docking of cytotoxic granules. Second, cytotoxic granules arrive and fuse upon docking in a SNARE-dependent manner. Following fusion, membrane components of the cytotoxic granule are retrieved through endocytosis to ensure the fast, efficient serial killing of target cells that is characteristic of cytotoxic T lymphocytes. Springer International Publishing 2016-09-01 2017 /pmc/articles/PMC5241346/ /pubmed/27585956 http://dx.doi.org/10.1007/s00018-016-2350-7 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Chang, Hsin-Fang
Bzeih, Hawraa
Chitirala, Praneeth
Ravichandran, Keerthana
Sleiman, Marwa
Krause, Elmar
Hahn, Ulrike
Pattu, Varsha
Rettig, Jens
Preparing the lethal hit: interplay between exo- and endocytic pathways in cytotoxic T lymphocytes
title Preparing the lethal hit: interplay between exo- and endocytic pathways in cytotoxic T lymphocytes
title_full Preparing the lethal hit: interplay between exo- and endocytic pathways in cytotoxic T lymphocytes
title_fullStr Preparing the lethal hit: interplay between exo- and endocytic pathways in cytotoxic T lymphocytes
title_full_unstemmed Preparing the lethal hit: interplay between exo- and endocytic pathways in cytotoxic T lymphocytes
title_short Preparing the lethal hit: interplay between exo- and endocytic pathways in cytotoxic T lymphocytes
title_sort preparing the lethal hit: interplay between exo- and endocytic pathways in cytotoxic t lymphocytes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241346/
https://www.ncbi.nlm.nih.gov/pubmed/27585956
http://dx.doi.org/10.1007/s00018-016-2350-7
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