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Preparing the lethal hit: interplay between exo- and endocytic pathways in cytotoxic T lymphocytes
Cytotoxic T lymphocytes patrol our body in search for infected cells which they kill through the release of cytotoxic substances contained in cytotoxic granules. The fusion of cytotoxic granules occurs at a specially formed contact site, the immunological synapse, and is tightly controlled to ensure...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241346/ https://www.ncbi.nlm.nih.gov/pubmed/27585956 http://dx.doi.org/10.1007/s00018-016-2350-7 |
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author | Chang, Hsin-Fang Bzeih, Hawraa Chitirala, Praneeth Ravichandran, Keerthana Sleiman, Marwa Krause, Elmar Hahn, Ulrike Pattu, Varsha Rettig, Jens |
author_facet | Chang, Hsin-Fang Bzeih, Hawraa Chitirala, Praneeth Ravichandran, Keerthana Sleiman, Marwa Krause, Elmar Hahn, Ulrike Pattu, Varsha Rettig, Jens |
author_sort | Chang, Hsin-Fang |
collection | PubMed |
description | Cytotoxic T lymphocytes patrol our body in search for infected cells which they kill through the release of cytotoxic substances contained in cytotoxic granules. The fusion of cytotoxic granules occurs at a specially formed contact site, the immunological synapse, and is tightly controlled to ensure specificity. In this review, we discuss the contribution of two intracellular compartments, endosomes and cytotoxic granules, to the formation, function and disassembly of the immunological synapse. We highlight a recently proposed sequential process of fusion events at the IS upon target cell recognition. First, recycling endosomes fuse with the plasma membrane to deliver cargo required for the docking of cytotoxic granules. Second, cytotoxic granules arrive and fuse upon docking in a SNARE-dependent manner. Following fusion, membrane components of the cytotoxic granule are retrieved through endocytosis to ensure the fast, efficient serial killing of target cells that is characteristic of cytotoxic T lymphocytes. |
format | Online Article Text |
id | pubmed-5241346 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-52413462017-02-01 Preparing the lethal hit: interplay between exo- and endocytic pathways in cytotoxic T lymphocytes Chang, Hsin-Fang Bzeih, Hawraa Chitirala, Praneeth Ravichandran, Keerthana Sleiman, Marwa Krause, Elmar Hahn, Ulrike Pattu, Varsha Rettig, Jens Cell Mol Life Sci Review Cytotoxic T lymphocytes patrol our body in search for infected cells which they kill through the release of cytotoxic substances contained in cytotoxic granules. The fusion of cytotoxic granules occurs at a specially formed contact site, the immunological synapse, and is tightly controlled to ensure specificity. In this review, we discuss the contribution of two intracellular compartments, endosomes and cytotoxic granules, to the formation, function and disassembly of the immunological synapse. We highlight a recently proposed sequential process of fusion events at the IS upon target cell recognition. First, recycling endosomes fuse with the plasma membrane to deliver cargo required for the docking of cytotoxic granules. Second, cytotoxic granules arrive and fuse upon docking in a SNARE-dependent manner. Following fusion, membrane components of the cytotoxic granule are retrieved through endocytosis to ensure the fast, efficient serial killing of target cells that is characteristic of cytotoxic T lymphocytes. Springer International Publishing 2016-09-01 2017 /pmc/articles/PMC5241346/ /pubmed/27585956 http://dx.doi.org/10.1007/s00018-016-2350-7 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Review Chang, Hsin-Fang Bzeih, Hawraa Chitirala, Praneeth Ravichandran, Keerthana Sleiman, Marwa Krause, Elmar Hahn, Ulrike Pattu, Varsha Rettig, Jens Preparing the lethal hit: interplay between exo- and endocytic pathways in cytotoxic T lymphocytes |
title | Preparing the lethal hit: interplay between exo- and endocytic pathways in cytotoxic T lymphocytes |
title_full | Preparing the lethal hit: interplay between exo- and endocytic pathways in cytotoxic T lymphocytes |
title_fullStr | Preparing the lethal hit: interplay between exo- and endocytic pathways in cytotoxic T lymphocytes |
title_full_unstemmed | Preparing the lethal hit: interplay between exo- and endocytic pathways in cytotoxic T lymphocytes |
title_short | Preparing the lethal hit: interplay between exo- and endocytic pathways in cytotoxic T lymphocytes |
title_sort | preparing the lethal hit: interplay between exo- and endocytic pathways in cytotoxic t lymphocytes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241346/ https://www.ncbi.nlm.nih.gov/pubmed/27585956 http://dx.doi.org/10.1007/s00018-016-2350-7 |
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