REC8 functions as a tumor suppressor and is epigenetically downregulated in gastric cancer, especially in EBV-positive subtype

REC8 meiotic recombination protein (REC8) was found to be preferentially methylated in gastric cancer (GC) using promoter methylation array. We aimed to elucidate the epigenetic alteration and biological function of REC8 in GC. REC8 was downregulated in 100% (3/3) of Epstein–Barr virus (EBV)-positiv...

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Detalles Bibliográficos
Autores principales: Yu, J, Liang, Q, Wang, J, Wang, K, Gao, J, Zhang, J, Zeng, Y, Chiu, P W Y, Ng, E K W, Sung, J J Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241426/
https://www.ncbi.nlm.nih.gov/pubmed/27212034
http://dx.doi.org/10.1038/onc.2016.187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241426/
https://www.ncbi.nlm.nih.gov/pubmed/27212034
http://dx.doi.org/10.1038/onc.2016.187

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