Gelatinous Marrow Transformation Associated with Imatinib: Case Report and Literature Review

Gelatinous marrow transformation (GMT) is a rare condition observed in severe illness or malnutrition, in which the bone marrow contains amorphous “gelatinous” extracellular material, and histopathology demonstrates varied degrees of fat cell atrophy and loss of hematopoietic elements. An associatio...

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Detalles Bibliográficos
Autores principales: Chang, E., Rivero, G., Jiang, B., Yellapragada, S., Thiagarajan, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241459/
https://www.ncbi.nlm.nih.gov/pubmed/28133556
http://dx.doi.org/10.1155/2017/1950724
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author Chang, E.
Rivero, G.
Jiang, B.
Yellapragada, S.
Thiagarajan, P.
author_facet Chang, E.
Rivero, G.
Jiang, B.
Yellapragada, S.
Thiagarajan, P.
author_sort Chang, E.
collection PubMed
description Gelatinous marrow transformation (GMT) is a rare condition observed in severe illness or malnutrition, in which the bone marrow contains amorphous “gelatinous” extracellular material, and histopathology demonstrates varied degrees of fat cell atrophy and loss of hematopoietic elements. An association of GMT with imatinib use in chronic myeloid leukemia (CML) has been reported recently. The objective of this study is to describe a case of GMT associated with imatinib use and review the existing similar cases in the literature to identify epidemiological patterns and potential imatinib-induced mechanisms leading to gelatinous conversion.
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spelling pubmed-52414592017-01-29 Gelatinous Marrow Transformation Associated with Imatinib: Case Report and Literature Review Chang, E. Rivero, G. Jiang, B. Yellapragada, S. Thiagarajan, P. Case Rep Hematol Case Report Gelatinous marrow transformation (GMT) is a rare condition observed in severe illness or malnutrition, in which the bone marrow contains amorphous “gelatinous” extracellular material, and histopathology demonstrates varied degrees of fat cell atrophy and loss of hematopoietic elements. An association of GMT with imatinib use in chronic myeloid leukemia (CML) has been reported recently. The objective of this study is to describe a case of GMT associated with imatinib use and review the existing similar cases in the literature to identify epidemiological patterns and potential imatinib-induced mechanisms leading to gelatinous conversion. Hindawi Publishing Corporation 2017 2017-01-04 /pmc/articles/PMC5241459/ /pubmed/28133556 http://dx.doi.org/10.1155/2017/1950724 Text en Copyright © 2017 E. Chang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Chang, E.
Rivero, G.
Jiang, B.
Yellapragada, S.
Thiagarajan, P.
Gelatinous Marrow Transformation Associated with Imatinib: Case Report and Literature Review
title Gelatinous Marrow Transformation Associated with Imatinib: Case Report and Literature Review
title_full Gelatinous Marrow Transformation Associated with Imatinib: Case Report and Literature Review
title_fullStr Gelatinous Marrow Transformation Associated with Imatinib: Case Report and Literature Review
title_full_unstemmed Gelatinous Marrow Transformation Associated with Imatinib: Case Report and Literature Review
title_short Gelatinous Marrow Transformation Associated with Imatinib: Case Report and Literature Review
title_sort gelatinous marrow transformation associated with imatinib: case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241459/
https://www.ncbi.nlm.nih.gov/pubmed/28133556
http://dx.doi.org/10.1155/2017/1950724
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AT yellapragadas gelatinousmarrowtransformationassociatedwithimatinibcasereportandliteraturereview
AT thiagarajanp gelatinousmarrowtransformationassociatedwithimatinibcasereportandliteraturereview

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