Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment

L-type amino acid transporters (LATs) mainly assist the uptake of neutral amino acids into cells. Four LATs (LAT1, LAT2, LAT3 and LAT4) have so far been identified. LAT1 (SLC7A5) has been attracting much attention in the field of cancer research since it is commonly up-regulated in various cancers....

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Detalles Bibliográficos
Autores principales: Hayashi, Keitaro, Anzai, Naohiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241523/
https://www.ncbi.nlm.nih.gov/pubmed/28144396
http://dx.doi.org/10.4251/wjgo.v9.i1.21
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author Hayashi, Keitaro
Anzai, Naohiko
author_facet Hayashi, Keitaro
Anzai, Naohiko
author_sort Hayashi, Keitaro
collection PubMed
description L-type amino acid transporters (LATs) mainly assist the uptake of neutral amino acids into cells. Four LATs (LAT1, LAT2, LAT3 and LAT4) have so far been identified. LAT1 (SLC7A5) has been attracting much attention in the field of cancer research since it is commonly up-regulated in various cancers. Basic research has made it increasingly clear that LAT1 plays a predominant role in malignancy. The functional significance of LAT1 in cancer and the potential therapeutic application of the features of LAT1 to cancer management are described in this review.
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spelling pubmed-52415232017-01-31 Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment Hayashi, Keitaro Anzai, Naohiko World J Gastrointest Oncol Review L-type amino acid transporters (LATs) mainly assist the uptake of neutral amino acids into cells. Four LATs (LAT1, LAT2, LAT3 and LAT4) have so far been identified. LAT1 (SLC7A5) has been attracting much attention in the field of cancer research since it is commonly up-regulated in various cancers. Basic research has made it increasingly clear that LAT1 plays a predominant role in malignancy. The functional significance of LAT1 in cancer and the potential therapeutic application of the features of LAT1 to cancer management are described in this review. Baishideng Publishing Group Inc 2017-01-15 2017-01-15 /pmc/articles/PMC5241523/ /pubmed/28144396 http://dx.doi.org/10.4251/wjgo.v9.i1.21 Text en ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Review
Hayashi, Keitaro
Anzai, Naohiko
Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment
title Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment
title_full Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment
title_fullStr Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment
title_full_unstemmed Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment
title_short Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment
title_sort novel therapeutic approaches targeting l-type amino acid transporters for cancer treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241523/
https://www.ncbi.nlm.nih.gov/pubmed/28144396
http://dx.doi.org/10.4251/wjgo.v9.i1.21
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