The association between poor sleep quality and global cortical atrophy is related to age. Results from the Atahualpa Project

Community-dwellers aged ≥60 years enrolled in the Atahualpa Project underwent brain MRI and were interviewed with the Pittsburgh Sleep Quality Index. Of 290 participants, 94 (32%) had poor sleep quality and 143 (49%) had global cortical atrophy (GCA). In a logistic regression model (adjusted for dem...

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Detalles Bibliográficos
Autores principales: Del Brutto, Oscar H., Mera, Robertino M., Zambrano, Mauricio, Castillo, Pablo R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241584/
https://www.ncbi.nlm.nih.gov/pubmed/28123651
http://dx.doi.org/10.1016/j.slsci.2016.06.004
Descripción
Sumario:Community-dwellers aged ≥60 years enrolled in the Atahualpa Project underwent brain MRI and were interviewed with the Pittsburgh Sleep Quality Index. Of 290 participants, 94 (32%) had poor sleep quality and 143 (49%) had global cortical atrophy (GCA). In a logistic regression model (adjusted for demographics, cardiovascular risk factor, severe edentulism, symptoms of depression, the MoCA score, and neuroimaging signatures of cerebrovascular damage), poor sleep quality was associated with GCA (p=0.004). A multivariate probability model showed that the probability of moderate-to-severe GCA significantly increased in individuals with poor sleep quality aged ≥67 years. This study provides evidence for an association between poor sleep quality and GCA in older adults and the important interaction of age in this association.

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