The association between poor sleep quality and global cortical atrophy is related to age. Results from the Atahualpa Project

Community-dwellers aged ≥60 years enrolled in the Atahualpa Project underwent brain MRI and were interviewed with the Pittsburgh Sleep Quality Index. Of 290 participants, 94 (32%) had poor sleep quality and 143 (49%) had global cortical atrophy (GCA). In a logistic regression model (adjusted for dem...

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Detalles Bibliográficos
Autores principales: Del Brutto, Oscar H., Mera, Robertino M., Zambrano, Mauricio, Castillo, Pablo R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241584/
https://www.ncbi.nlm.nih.gov/pubmed/28123651
http://dx.doi.org/10.1016/j.slsci.2016.06.004
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author Del Brutto, Oscar H.
Mera, Robertino M.
Zambrano, Mauricio
Castillo, Pablo R.
author_facet Del Brutto, Oscar H.
Mera, Robertino M.
Zambrano, Mauricio
Castillo, Pablo R.
author_sort Del Brutto, Oscar H.
collection PubMed
description Community-dwellers aged ≥60 years enrolled in the Atahualpa Project underwent brain MRI and were interviewed with the Pittsburgh Sleep Quality Index. Of 290 participants, 94 (32%) had poor sleep quality and 143 (49%) had global cortical atrophy (GCA). In a logistic regression model (adjusted for demographics, cardiovascular risk factor, severe edentulism, symptoms of depression, the MoCA score, and neuroimaging signatures of cerebrovascular damage), poor sleep quality was associated with GCA (p=0.004). A multivariate probability model showed that the probability of moderate-to-severe GCA significantly increased in individuals with poor sleep quality aged ≥67 years. This study provides evidence for an association between poor sleep quality and GCA in older adults and the important interaction of age in this association.
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spelling pubmed-52415842017-01-25 The association between poor sleep quality and global cortical atrophy is related to age. Results from the Atahualpa Project Del Brutto, Oscar H. Mera, Robertino M. Zambrano, Mauricio Castillo, Pablo R. Sleep Sci Short Communication Community-dwellers aged ≥60 years enrolled in the Atahualpa Project underwent brain MRI and were interviewed with the Pittsburgh Sleep Quality Index. Of 290 participants, 94 (32%) had poor sleep quality and 143 (49%) had global cortical atrophy (GCA). In a logistic regression model (adjusted for demographics, cardiovascular risk factor, severe edentulism, symptoms of depression, the MoCA score, and neuroimaging signatures of cerebrovascular damage), poor sleep quality was associated with GCA (p=0.004). A multivariate probability model showed that the probability of moderate-to-severe GCA significantly increased in individuals with poor sleep quality aged ≥67 years. This study provides evidence for an association between poor sleep quality and GCA in older adults and the important interaction of age in this association. Elsevier 2016 2016-09-09 /pmc/articles/PMC5241584/ /pubmed/28123651 http://dx.doi.org/10.1016/j.slsci.2016.06.004 Text en © 2016 Brazilian Association of Sleep. Production and Hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Short Communication
Del Brutto, Oscar H.
Mera, Robertino M.
Zambrano, Mauricio
Castillo, Pablo R.
The association between poor sleep quality and global cortical atrophy is related to age. Results from the Atahualpa Project
title The association between poor sleep quality and global cortical atrophy is related to age. Results from the Atahualpa Project
title_full The association between poor sleep quality and global cortical atrophy is related to age. Results from the Atahualpa Project
title_fullStr The association between poor sleep quality and global cortical atrophy is related to age. Results from the Atahualpa Project
title_full_unstemmed The association between poor sleep quality and global cortical atrophy is related to age. Results from the Atahualpa Project
title_short The association between poor sleep quality and global cortical atrophy is related to age. Results from the Atahualpa Project
title_sort association between poor sleep quality and global cortical atrophy is related to age. results from the atahualpa project
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241584/
https://www.ncbi.nlm.nih.gov/pubmed/28123651
http://dx.doi.org/10.1016/j.slsci.2016.06.004
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