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A hypothetic aging pathway from skin to hypothalamic suprachiasmatic nucleus via slow wave sleep
Many observations have demonstrated that the hypothalamic neuroendocrine change determines the chronological sequence of aging in mammals. However, it remains uncertain on the mechanism to account for the hypothalamic aging manifestations. In this article, it is pointed out that, as constantly expos...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Elsevier
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241610/ https://www.ncbi.nlm.nih.gov/pubmed/28123663 http://dx.doi.org/10.1016/j.slsci.2016.09.004 |
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author | Cai, Zi-Jian |
author_facet | Cai, Zi-Jian |
author_sort | Cai, Zi-Jian |
collection | PubMed |
description | Many observations have demonstrated that the hypothalamic neuroendocrine change determines the chronological sequence of aging in mammals. However, it remains uncertain on the mechanism to account for the hypothalamic aging manifestations. In this article, it is pointed out that, as constantly exposed to sunshine and oxygen, the skin would undergo both telomere-shortening and oxidative senescent processes. The senescent alterations of skin, such as attenuation in electrodermal activities, would in turn reduce the emotional responses and memories. Whereas previously I demonstrated that the slow wave sleep just functioned to adjust the emotional balance disrupted by accumulated emotional memories, especially capable of ameliorating the symptoms of depressed patients. Therefore, the reduction in emotional responses and memories from skin senescence would reduce the requirement for slow wave sleep in many senescent observations. The decrement in slow wave sleep would in further cause functional but not chronological degeneration of suprachiasmatic nucleus rather than paraventricular nucleus in hypothalamus. In these respects, from skin senescence to slow wave sleep, there forms a new degenerative aging pathway able to account for the hypothalamic chronological sequence of aging, specifically addressed to the suprachiasmatic nucleus. |
format | Online Article Text |
id | pubmed-5241610 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-52416102017-01-25 A hypothetic aging pathway from skin to hypothalamic suprachiasmatic nucleus via slow wave sleep Cai, Zi-Jian Sleep Sci Full Length Article Many observations have demonstrated that the hypothalamic neuroendocrine change determines the chronological sequence of aging in mammals. However, it remains uncertain on the mechanism to account for the hypothalamic aging manifestations. In this article, it is pointed out that, as constantly exposed to sunshine and oxygen, the skin would undergo both telomere-shortening and oxidative senescent processes. The senescent alterations of skin, such as attenuation in electrodermal activities, would in turn reduce the emotional responses and memories. Whereas previously I demonstrated that the slow wave sleep just functioned to adjust the emotional balance disrupted by accumulated emotional memories, especially capable of ameliorating the symptoms of depressed patients. Therefore, the reduction in emotional responses and memories from skin senescence would reduce the requirement for slow wave sleep in many senescent observations. The decrement in slow wave sleep would in further cause functional but not chronological degeneration of suprachiasmatic nucleus rather than paraventricular nucleus in hypothalamus. In these respects, from skin senescence to slow wave sleep, there forms a new degenerative aging pathway able to account for the hypothalamic chronological sequence of aging, specifically addressed to the suprachiasmatic nucleus. Elsevier 2016 2016-10-13 /pmc/articles/PMC5241610/ /pubmed/28123663 http://dx.doi.org/10.1016/j.slsci.2016.09.004 Text en © 2016 Brazilian Association of Sleep. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Full Length Article Cai, Zi-Jian A hypothetic aging pathway from skin to hypothalamic suprachiasmatic nucleus via slow wave sleep |
title | A hypothetic aging pathway from skin to hypothalamic suprachiasmatic nucleus via slow wave sleep |
title_full | A hypothetic aging pathway from skin to hypothalamic suprachiasmatic nucleus via slow wave sleep |
title_fullStr | A hypothetic aging pathway from skin to hypothalamic suprachiasmatic nucleus via slow wave sleep |
title_full_unstemmed | A hypothetic aging pathway from skin to hypothalamic suprachiasmatic nucleus via slow wave sleep |
title_short | A hypothetic aging pathway from skin to hypothalamic suprachiasmatic nucleus via slow wave sleep |
title_sort | hypothetic aging pathway from skin to hypothalamic suprachiasmatic nucleus via slow wave sleep |
topic | Full Length Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241610/ https://www.ncbi.nlm.nih.gov/pubmed/28123663 http://dx.doi.org/10.1016/j.slsci.2016.09.004 |
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