Cargando…

Translesion Synthesis of 2′-Deoxyguanosine Lesions by Eukaryotic DNA Polymerases

[Image: see text] With the discovery of translesion synthesis DNA polymerases, great strides have been made in the last two decades in understanding the mode of replication of various DNA lesions in prokaryotes and eukaryotes. A database search indicated that approximately 2000 articles on this topi...

Descripción completa

Detalles Bibliográficos
Autores principales: Basu, Ashis K., Pande, Paritosh, Bose, Arindam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241707/
https://www.ncbi.nlm.nih.gov/pubmed/27760288
http://dx.doi.org/10.1021/acs.chemrestox.6b00285
_version_ 1782496231215333376
author Basu, Ashis K.
Pande, Paritosh
Bose, Arindam
author_facet Basu, Ashis K.
Pande, Paritosh
Bose, Arindam
author_sort Basu, Ashis K.
collection PubMed
description [Image: see text] With the discovery of translesion synthesis DNA polymerases, great strides have been made in the last two decades in understanding the mode of replication of various DNA lesions in prokaryotes and eukaryotes. A database search indicated that approximately 2000 articles on this topic have been published in this period. This includes research involving genetic and structural studies as well as in vitro experiments using purified DNA polymerases and accessory proteins. It is a daunting task to comprehend this exciting and rapidly emerging area of research. Even so, as the majority of DNA damage occurs at 2′-deoxyguanosine residues, this perspective attempts to summarize a subset of this field, focusing on the most relevant eukaryotic DNA polymerases responsible for their bypass.
format Online
Article
Text
id pubmed-5241707
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-52417072017-01-19 Translesion Synthesis of 2′-Deoxyguanosine Lesions by Eukaryotic DNA Polymerases Basu, Ashis K. Pande, Paritosh Bose, Arindam Chem Res Toxicol [Image: see text] With the discovery of translesion synthesis DNA polymerases, great strides have been made in the last two decades in understanding the mode of replication of various DNA lesions in prokaryotes and eukaryotes. A database search indicated that approximately 2000 articles on this topic have been published in this period. This includes research involving genetic and structural studies as well as in vitro experiments using purified DNA polymerases and accessory proteins. It is a daunting task to comprehend this exciting and rapidly emerging area of research. Even so, as the majority of DNA damage occurs at 2′-deoxyguanosine residues, this perspective attempts to summarize a subset of this field, focusing on the most relevant eukaryotic DNA polymerases responsible for their bypass. American Chemical Society 2016-10-19 2017-01-17 /pmc/articles/PMC5241707/ /pubmed/27760288 http://dx.doi.org/10.1021/acs.chemrestox.6b00285 Text en Copyright © 2016 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Basu, Ashis K.
Pande, Paritosh
Bose, Arindam
Translesion Synthesis of 2′-Deoxyguanosine Lesions by Eukaryotic DNA Polymerases
title Translesion Synthesis of 2′-Deoxyguanosine Lesions by Eukaryotic DNA Polymerases
title_full Translesion Synthesis of 2′-Deoxyguanosine Lesions by Eukaryotic DNA Polymerases
title_fullStr Translesion Synthesis of 2′-Deoxyguanosine Lesions by Eukaryotic DNA Polymerases
title_full_unstemmed Translesion Synthesis of 2′-Deoxyguanosine Lesions by Eukaryotic DNA Polymerases
title_short Translesion Synthesis of 2′-Deoxyguanosine Lesions by Eukaryotic DNA Polymerases
title_sort translesion synthesis of 2′-deoxyguanosine lesions by eukaryotic dna polymerases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241707/
https://www.ncbi.nlm.nih.gov/pubmed/27760288
http://dx.doi.org/10.1021/acs.chemrestox.6b00285
work_keys_str_mv AT basuashisk translesionsynthesisof2deoxyguanosinelesionsbyeukaryoticdnapolymerases
AT pandeparitosh translesionsynthesisof2deoxyguanosinelesionsbyeukaryoticdnapolymerases
AT bosearindam translesionsynthesisof2deoxyguanosinelesionsbyeukaryoticdnapolymerases