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Structure of the Toll/Interleukin-1 Receptor (TIR) Domain of the B-cell Adaptor That Links Phosphoinositide Metabolism with the Negative Regulation of the Toll-like Receptor (TLR) Signalosome

Ligand binding to Toll-like receptors (TLRs) results in dimerization of their cytosolic Toll/interleukin-1 receptor (TIR) domains and recruitment of post-receptor signal transducers into a complex signalosome. TLR activation leads to the production of transcription factors and pro-inflammatory molec...

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Detalles Bibliográficos
Autores principales:	Halabi, Samer, Sekine, Eiki, Verstak, Brett, Gay, Nicholas J., Moncrieffe, Martin C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241739/ https://www.ncbi.nlm.nih.gov/pubmed/27909057 http://dx.doi.org/10.1074/jbc.M116.761528

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