A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis

T helper 9 (Th9) cells contribute to lung inflammation and allergy as sources of interleukin-9 (IL-9). However, the mechanisms by which IL-9/Th9 mediate immunopathology in the lung are unknown. Here we report an IL-9-driven positive feedback loop that reinforces allergic inflammation. We show that I...

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Detalles Bibliográficos
Autores principales: Moretti, Silvia, Renga, Giorgia, Oikonomou, Vasilis, Galosi, Claudia, Pariano, Marilena, Iannitti, Rossana G., Borghi, Monica, Puccetti, Matteo, De Zuani, Marco, Pucillo, Carlo E., Paolicelli, Giuseppe, Zelante, Teresa, Renauld, Jean-Christophe, Bereshchenko, Oxana, Sportoletti, Paolo, Lucidi, Vincenzina, Russo, Maria Chiara, Colombo, Carla, Fiscarelli, Ersilia, Lass-Flörl, Cornelia, Majo, Fabio, Ricciotti, Gabriella, Ellemunter, Helmut, Ratclif, Luigi, Talesa, Vincenzo Nicola, Napolioni, Valerio, Romani, Luigina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241810/
https://www.ncbi.nlm.nih.gov/pubmed/28090087
http://dx.doi.org/10.1038/ncomms14017

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