K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression

T-cell proliferation is regulated by ubiquitination but the underlying molecular mechanism remains obscure. Here we report that Lys-48-linked ubiquitination of the transcription factor KLF4 mediated by the E3 ligase Mule promotes T-cell entry into S phase. Mule is elevated in T cells upon TCR engage...

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Detalles Bibliográficos
Autores principales: Hao, Zhenyue, Sheng, Yi, Duncan, Gordon S., Li, Wanda Y., Dominguez, Carmen, Sylvester, Jennifer, Su, Yu-Wen, Lin, Gloria H.Y., Snow, Bryan E., Brenner, Dirk, You-Ten, Annick, Haight, Jillian, Inoue, Satoshi, Wakeham, Andrew, Elford, Alisha, Hamilton, Sara, Liang, Yi, Zúñiga-Pflücker, Juan C., He, Housheng Hansen, Ohashi, Pamela S., Mak, Tak W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241832/
https://www.ncbi.nlm.nih.gov/pubmed/28084302
http://dx.doi.org/10.1038/ncomms14003

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