Dopamine promotes NMDA receptor hypofunction in the retina through D(1) receptor-mediated Csk activation, Src inhibition and decrease of GluN2B phosphorylation

Dopamine and glutamate are critical neurotransmitters involved in light-induced synaptic activity in the retina. In brain neurons, dopamine D(1) receptors (D(1)Rs) and the cytosolic protein tyrosine kinase Src can, independently, modulate the behavior of NMDA-type glutamate receptors (NMDARs). Here...

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Detalles Bibliográficos
Autores principales: Socodato, Renato, Santiago, Felipe N., Portugal, Camila C., Domith, Ivan, Encarnação, Thaísa G., Loiola, Erick C., Ventura, Ana L. M., Cossenza, Marcelo, Relvas, João B., Castro, Newton G., Paes-de-Carvalho, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241882/
https://www.ncbi.nlm.nih.gov/pubmed/28098256
http://dx.doi.org/10.1038/srep40912

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