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Benzene poisoning, clinical and blood abnormalities in two Brazilian female gas station attendants: two case reports
BACKGROUND: Brazilian gas station workers are chronically exposed to benzene, toluene, xylene (BTX) during their working time. Describe below two cases of latin female gas station workers with benzene poisoning symptoms and miscarriage history. CASE PRESENTATION: In both cases were identified comple...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241924/ https://www.ncbi.nlm.nih.gov/pubmed/28100263 http://dx.doi.org/10.1186/s13104-016-2369-8 |
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author | Santiago, Fábio Lima, Simone Pinheiro, Tayná Silvestre, Rafaele Tavares Otero, Ubirani Barros Tabalipa, Marianne Medeiros Kosyakova, Nadezda Ornellas, Maria Helena Liehr, Thomas Alves, Gilda |
author_facet | Santiago, Fábio Lima, Simone Pinheiro, Tayná Silvestre, Rafaele Tavares Otero, Ubirani Barros Tabalipa, Marianne Medeiros Kosyakova, Nadezda Ornellas, Maria Helena Liehr, Thomas Alves, Gilda |
author_sort | Santiago, Fábio |
collection | PubMed |
description | BACKGROUND: Brazilian gas station workers are chronically exposed to benzene, toluene, xylene (BTX) during their working time. Describe below two cases of latin female gas station workers with benzene poisoning symptoms and miscarriage history. CASE PRESENTATION: In both cases were identified complex chromosomal rearrangements (CCR) with fluorescence in situ hybridization, applied to whole chromosome paints by chromosomes 1, 2 and 4. The lower natural killer cell (NK) cells have also been observed in cases correspondents, especially the rare type of NK (NKbright) in their peripheral blood cells. CONCLUSIONS: It is known that acquired chromosomal aberrations are positively correlated with cancer and reproductive risk. In concordance, lower NK cytotoxicity increases the risk for cancer, as well. Thus, this is the first study providing hints on a possible causative relation of lower NK cytotoxicity and increase rates of chromosomal rearrangements including CCRs. |
format | Online Article Text |
id | pubmed-5241924 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-52419242017-01-23 Benzene poisoning, clinical and blood abnormalities in two Brazilian female gas station attendants: two case reports Santiago, Fábio Lima, Simone Pinheiro, Tayná Silvestre, Rafaele Tavares Otero, Ubirani Barros Tabalipa, Marianne Medeiros Kosyakova, Nadezda Ornellas, Maria Helena Liehr, Thomas Alves, Gilda BMC Res Notes Case Report BACKGROUND: Brazilian gas station workers are chronically exposed to benzene, toluene, xylene (BTX) during their working time. Describe below two cases of latin female gas station workers with benzene poisoning symptoms and miscarriage history. CASE PRESENTATION: In both cases were identified complex chromosomal rearrangements (CCR) with fluorescence in situ hybridization, applied to whole chromosome paints by chromosomes 1, 2 and 4. The lower natural killer cell (NK) cells have also been observed in cases correspondents, especially the rare type of NK (NKbright) in their peripheral blood cells. CONCLUSIONS: It is known that acquired chromosomal aberrations are positively correlated with cancer and reproductive risk. In concordance, lower NK cytotoxicity increases the risk for cancer, as well. Thus, this is the first study providing hints on a possible causative relation of lower NK cytotoxicity and increase rates of chromosomal rearrangements including CCRs. BioMed Central 2017-01-18 /pmc/articles/PMC5241924/ /pubmed/28100263 http://dx.doi.org/10.1186/s13104-016-2369-8 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Santiago, Fábio Lima, Simone Pinheiro, Tayná Silvestre, Rafaele Tavares Otero, Ubirani Barros Tabalipa, Marianne Medeiros Kosyakova, Nadezda Ornellas, Maria Helena Liehr, Thomas Alves, Gilda Benzene poisoning, clinical and blood abnormalities in two Brazilian female gas station attendants: two case reports |
title | Benzene poisoning, clinical and blood abnormalities in two Brazilian female gas station attendants: two case reports |
title_full | Benzene poisoning, clinical and blood abnormalities in two Brazilian female gas station attendants: two case reports |
title_fullStr | Benzene poisoning, clinical and blood abnormalities in two Brazilian female gas station attendants: two case reports |
title_full_unstemmed | Benzene poisoning, clinical and blood abnormalities in two Brazilian female gas station attendants: two case reports |
title_short | Benzene poisoning, clinical and blood abnormalities in two Brazilian female gas station attendants: two case reports |
title_sort | benzene poisoning, clinical and blood abnormalities in two brazilian female gas station attendants: two case reports |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241924/ https://www.ncbi.nlm.nih.gov/pubmed/28100263 http://dx.doi.org/10.1186/s13104-016-2369-8 |
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