High-throughput expression of animal venom toxins in Escherichia coli to generate a large library of oxidized disulphide-reticulated peptides for drug discovery

BACKGROUND: Animal venoms are complex molecular cocktails containing a wide range of biologically active disulphide-reticulated peptides that target, with high selectivity and efficacy, a variety of membrane receptors. Disulphide-reticulated peptides have evolved to display improved specificity, low...

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Detalles Bibliográficos
Autores principales: Turchetto, Jeremy, Sequeira, Ana Filipa, Ramond, Laurie, Peysson, Fanny, Brás, Joana L. A., Saez, Natalie J., Duhoo, Yoan, Blémont, Marilyne, Guerreiro, Catarina I. P. D., Quinton, Loic, De Pauw, Edwin, Gilles, Nicolas, Darbon, Hervé, Fontes, Carlos M. G. A., Vincentelli, Renaud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242012/
https://www.ncbi.nlm.nih.gov/pubmed/28095880
http://dx.doi.org/10.1186/s12934-016-0617-1

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