Citrate functionalized Mn(3)O(4) in nanotherapy of hepatic fibrosis by oral administration

AIM: To test the potential of orally administered citrate functionalized Mn(3)O(4) nanoparticles (C-Mn(3)O(4) NPs) as a therapeutic agent against hepatic fibrosis and associated chronic liver diseases. MATERIALS & METHODS: C-Mn(3)O(4) NPs were synthesized and the pH dependent antioxidant mechani...

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Autores principales: Adhikari, Aniruddha, Polley, Nabarun, Darbar, Soumendra, Bagchi, Damayanti, Pal, Samir Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242211/
https://www.ncbi.nlm.nih.gov/pubmed/28116129
http://dx.doi.org/10.4155/fsoa-2016-0029
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author Adhikari, Aniruddha
Polley, Nabarun
Darbar, Soumendra
Bagchi, Damayanti
Pal, Samir Kumar
author_facet Adhikari, Aniruddha
Polley, Nabarun
Darbar, Soumendra
Bagchi, Damayanti
Pal, Samir Kumar
author_sort Adhikari, Aniruddha
collection PubMed
description AIM: To test the potential of orally administered citrate functionalized Mn(3)O(4) nanoparticles (C-Mn(3)O(4) NPs) as a therapeutic agent against hepatic fibrosis and associated chronic liver diseases. MATERIALS & METHODS: C-Mn(3)O(4) NPs were synthesized and the pH dependent antioxidant mechanism was characterized by in vitro studies. CCl(4) intoxicated mice were orally treated with C-Mn(3)O(4) NPs to test its in vivo antioxidant and antifibrotic ability. RESULTS: We demonstrated ultrahigh efficacy of the C-Mn(3)O(4) NPs in treatment of chronic liver diseases such as hepatic fibrosis and cirrhosis in mice compared with conventional medicine silymarin without any toxicological implications. CONCLUSION: These findings may pave the way for practical clinical use of the NPs as safe medication of chronic liver diseases associated with fibrosis and cirrhosis in human subjects.
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spelling pubmed-52422112017-01-23 Citrate functionalized Mn(3)O(4) in nanotherapy of hepatic fibrosis by oral administration Adhikari, Aniruddha Polley, Nabarun Darbar, Soumendra Bagchi, Damayanti Pal, Samir Kumar Future Sci OA Research Article AIM: To test the potential of orally administered citrate functionalized Mn(3)O(4) nanoparticles (C-Mn(3)O(4) NPs) as a therapeutic agent against hepatic fibrosis and associated chronic liver diseases. MATERIALS & METHODS: C-Mn(3)O(4) NPs were synthesized and the pH dependent antioxidant mechanism was characterized by in vitro studies. CCl(4) intoxicated mice were orally treated with C-Mn(3)O(4) NPs to test its in vivo antioxidant and antifibrotic ability. RESULTS: We demonstrated ultrahigh efficacy of the C-Mn(3)O(4) NPs in treatment of chronic liver diseases such as hepatic fibrosis and cirrhosis in mice compared with conventional medicine silymarin without any toxicological implications. CONCLUSION: These findings may pave the way for practical clinical use of the NPs as safe medication of chronic liver diseases associated with fibrosis and cirrhosis in human subjects. Future Science Ltd 2016-10-06 /pmc/articles/PMC5242211/ /pubmed/28116129 http://dx.doi.org/10.4155/fsoa-2016-0029 Text en © Samir Kumar Pal This work is licensed under a Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/)
spellingShingle Research Article
Adhikari, Aniruddha
Polley, Nabarun
Darbar, Soumendra
Bagchi, Damayanti
Pal, Samir Kumar
Citrate functionalized Mn(3)O(4) in nanotherapy of hepatic fibrosis by oral administration
title Citrate functionalized Mn(3)O(4) in nanotherapy of hepatic fibrosis by oral administration
title_full Citrate functionalized Mn(3)O(4) in nanotherapy of hepatic fibrosis by oral administration
title_fullStr Citrate functionalized Mn(3)O(4) in nanotherapy of hepatic fibrosis by oral administration
title_full_unstemmed Citrate functionalized Mn(3)O(4) in nanotherapy of hepatic fibrosis by oral administration
title_short Citrate functionalized Mn(3)O(4) in nanotherapy of hepatic fibrosis by oral administration
title_sort citrate functionalized mn(3)o(4) in nanotherapy of hepatic fibrosis by oral administration
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242211/
https://www.ncbi.nlm.nih.gov/pubmed/28116129
http://dx.doi.org/10.4155/fsoa-2016-0029
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