Dietary rapamycin supplementation reverses age‐related vascular dysfunction and oxidative stress, while modulating nutrient‐sensing, cell cycle, and senescence pathways

Inhibition of mammalian target of rapamycin, mTOR, extends lifespan and reduces age‐related disease. It is not known what role mTOR plays in the arterial aging phenotype or if mTOR inhibition by dietary rapamycin ameliorates age‐related arterial dysfunction. To explore this, young (3.8 ± 0.6 months)...

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Detalles Bibliográficos
Autores principales: Lesniewski, Lisa A., Seals, Douglas R., Walker, Ashley E., Henson, Grant D., Blimline, Mark W., Trott, Daniel W., Bosshardt, Gary C., LaRocca, Thomas J., Lawson, Brooke R., Zigler, Melanie C., Donato, Anthony J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242306/
https://www.ncbi.nlm.nih.gov/pubmed/27660040
http://dx.doi.org/10.1111/acel.12524

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