Senescent Atrophic Epidermis Retains Lrig1+ Stem Cells and Loses Wnt Signaling, a Phenotype Shared with CD44KO Mice

Lrig1 is known to repress the epidermal growth through its inhibitory activity on EGFR, while CD44 promotes it. We analyzed the expression of these molecules in senescent atrophic human epidermis and in the epidermis of CD44KO mice. In normal human epidermis, Lrig1+ cells form clusters located in th...

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Detalles Bibliográficos
Autores principales: Barnes, Laurent, Saurat, Jean-Hilaire, Kaya, Gürkan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242443/
https://www.ncbi.nlm.nih.gov/pubmed/28099467
http://dx.doi.org/10.1371/journal.pone.0169452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242443/
https://www.ncbi.nlm.nih.gov/pubmed/28099467
http://dx.doi.org/10.1371/journal.pone.0169452

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