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CRISPR-Cas9 Mediated NOX4 Knockout Inhibits Cell Proliferation and Invasion in HeLa Cells

Increased expression of NOX4 protein is associated with cancer progression and metastasis but the role of NOX4 in cell proliferation and invasion is not fully understood. We generated NOX4 knockout HeLa cell lines using the CRISPR-Cas9 gene editing system to explore the cellular functions of NOX4. A...

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Detalles Bibliográficos
Autores principales:	Jafari, Naser, Kim, Hyunju, Park, Rackhyun, Li, Liqing, Jang, Minsu, Morris, Andrew J., Park, Junsoo, Huang, Cai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242459/ https://www.ncbi.nlm.nih.gov/pubmed/28099519 http://dx.doi.org/10.1371/journal.pone.0170327

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