Cargando…

Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo

BACKGROUND: Recent epidemiological evidence has linked hypoxia with the development of Alzheimer disease (AD). A number of in vitro and in vivo studies have reported that hypoxia can induce amyloid-β peptide accumulation through various molecular mechanisms including the up-regulation of the amyloid...

Descripción completa

Detalles Bibliográficos
Autores principales:	Serrano-Pozo, Alberto, Sánchez-García, Manuel A., Heras-Garvín, Antonio, March-Díaz, Rosana, Navarro, Victoria, Vizuete, Marisa, López-Barneo, José, Vitorica, Javier, Pascual, Alberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242476/ https://www.ncbi.nlm.nih.gov/pubmed/28099462 http://dx.doi.org/10.1371/journal.pone.0170345

Ejemplares similares

Correction: Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo
Publicado: (2017)

Disruption of Amyloid Plaques Integrity Affects the Soluble Oligomers Content from Alzheimer Disease Brains
por: Jimenez, Sebastian, et al.
Publicado: (2014)

Should We Open Fire on Microglia? Depletion Models as Tools to Elucidate Microglial Role in Health and Alzheimer’s Disease
por: Romero-Molina, Carmen, et al.
Publicado: (2021)

Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer’s disease hippocampus
por: Muñoz-Castro, Clara, et al.
Publicado: (2023)

Microglia in Alzheimer’s Disease: Activated, Dysfunctional or Degenerative
por: Navarro, Victoria, et al.
Publicado: (2018)

Acute Oxygen Sensing in Heme Oxygenase-2 Null Mice
por: Ortega-Sáenz, Patricia, et al.
Publicado: (2006)

Soluble phospho-tau from Alzheimer’s disease hippocampus drives microglial degeneration
por: Sanchez-Mejias, Elisabeth, et al.
Publicado: (2016)

Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus
por: Torres, Manuel, et al.
Publicado: (2012)

Signs of Chronic Hypoxia Suggest a Novel Pathophysiological Event in α‐Synucleinopathies
por: Heras‐Garvin, Antonio, et al.
Publicado: (2020)

Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology
por: Romero-Molina, Carmen, et al.
Publicado: (2018)

GDNF-based therapies, GDNF-producing interneurons, and trophic support of the dopaminergic nigrostriatal pathway. Implications for Parkinson’s disease
por: d’Anglemont de Tassigny, Xavier, et al.
Publicado: (2015)

COVID-19 therapies: do we see substantial progress?
por: Matusewicz, Lucyna, et al.
Publicado: (2022)

Age-Mediated Transcriptomic Changes in Adult Mouse Substantia Nigra
por: Gao, Lin, et al.
Publicado: (2013)

Deletion of the von Hippel–Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor-mediated adaptation to hypoxia
por: Macías, David, et al.
Publicado: (2014)

Substantiating Nexus Between Consumption Values and Sustainable Consumption Behavior: A Way Toward Sustainable Business
por: Sun, Jianmin, et al.
Publicado: (2022)

Using allometric procedures to substantiate the plastochrone method for eelgrass leaf growth assessments
por: Echavarría-Heras, Héctor, et al.
Publicado: (2013)

Phylogenetically Clustered Extinction Risks Do Not Substantially Prune the Tree of Life
por: Parhar, Rakesh K., et al.
Publicado: (2011)

Substantial fibrin amyloidogenesis in type 2 diabetes assessed using amyloid-selective fluorescent stains
por: Pretorius, Etheresia, et al.
Publicado: (2017)

Substantial and sustained seizure reduction with ketogenic diet in a patient with Ohtahara syndrome
por: Sivaraju, Adithya, et al.
Publicado: (2015)

Carotid body chemosensory responses in mice deficient of TASK channels
por: Ortega-Sáenz, Patricia, et al.
Publicado: (2010)

Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis
por: Sanchez-Varo, Raquel, et al.
Publicado: (2021)

Editorial: Hypoxia and Cardiorespiratory Control
por: Okada, Yasumasa, et al.
Publicado: (2021)

Adolescent idiopathic scoliosis and spinal fusion do not substantially impact on postural balance
por: Schimmel, Janneke JP, et al.
Publicado: (2015)

Same-gender citations do not indicate a substantial gender homophily bias
por: Tekles, Alexander, et al.
Publicado: (2022)

Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer’s disease model
por: Fernandez-Valenzuela, Juan Jose, et al.
Publicado: (2020)

Rapid degeneration of iPSC-derived motor neurons lacking Gdap1 engages a mitochondrial-sustained innate immune response
por: León, Marian, et al.
Publicado: (2023)

In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology
por: Trujillo-Estrada, Laura, et al.
Publicado: (2013)

Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease
por: Gomez‐Arboledas, Angela, et al.
Publicado: (2017)

Proteins Do Not Replicate, They Precipitate: Phase Transition and Loss of Function Toxicity in Amyloid Pathologies
por: Ezzat, Kariem, et al.
Publicado: (2022)

Priority Actions and Progress to Substantially and Sustainably Reduce the Mortality, Morbidity and Socioeconomic Burden of Tropical Snakebite
por: Harrison, Robert A., et al.
Publicado: (2016)

Substantiating efficacy of probiotics
por: Mercenier, Annick
Publicado: (2011)

Substantial Annual Distribution
Publicado: (1920)

Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease
por: Baglietto-Vargas, David, et al.
Publicado: (2017)

From Synaptic Protein to Prion: The Long and Controversial Journey of α-Synuclein
por: Heras-Garvin, Antonio, et al.
Publicado: (2020)

Technology, sustainability and educational innovation (TSIE)
por: Basantes-Andrade, Andrea, et al.
Publicado: (2020)

Substantial clinical benefit values demonstrate a high degree of variability when stratified by time and geographic region
por: Wellington, Ian J., et al.
Publicado: (2022)

Paris Agreement requires substantial, broad, and sustained policy efforts beyond COVID-19 public stimulus packages
por: Tanaka, Katsumasa, et al.
Publicado: (2022)

Food protein-derived amyloids do not accelerate amyloid β aggregation
por: Rahman, M. Mahafuzur, et al.
Publicado: (2023)

Breaking Up (Amyloid) Is Hard to Do
por: Gandy, Sam, et al.
Publicado: (2005)

Oat Plant Amyloids for Sustainable Functional Materials
por: Zhou, Jiangtao, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_4f5ujo0fj445k2239cdp2mm4qq