Correlations of Behavioral Deficits with Brain Pathology Assessed through Longitudinal MRI and Histopathology in the HdhQ150/Q150 Mouse Model of Huntington’s Disease

A variety of mouse models have been developed that express mutant huntingtin (mHTT) leading to aggregates and inclusions that model the molecular pathology observed in Huntington’s disease. Here we show that although homozygous HdhQ150 knock-in mice developed motor impairments (rotarod, locomotor ac...

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Detalles Bibliográficos
Autores principales: Rattray, Ivan, Smith, Edward J., Crum, William R., Walker, Thomas A., Gale, Richard, Bates, Gillian P., Modo, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242535/
https://www.ncbi.nlm.nih.gov/pubmed/28099507
http://dx.doi.org/10.1371/journal.pone.0168556

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