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The Effect of Selective D- or N(α)-Methyl Arginine Substitution on the Activity of the Proline-Rich Antimicrobial Peptide, Chex1-Arg20

In vivo pharmacokinetics studies have shown that the proline-rich antimicrobial peptide, A3-APO, which is a discontinuous dimer of the peptide, Chex1-Arg20, undergoes degradation to small fragments at positions Pro6-Arg7 and Val19-Arg20. With the aim of minimizing or abolishing this degradation, a s...

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Detalles Bibliográficos
Autores principales:	Li, Wenyi, Sun, Zhe, O'Brien-Simpson, Neil M., Otvos, Laszlo, Reynolds, Eric C., Hossain, Mohammed A., Separovic, Frances, Wade, John D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243837/ https://www.ncbi.nlm.nih.gov/pubmed/28154813 http://dx.doi.org/10.3389/fchem.2017.00001

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