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Regulation of NK Cell Activation and Effector Functions by the IL-12 Family of Cytokines: The Case of IL-27

Natural killer (NK) cells are characterized by their ability to detect and induce apoptosis of susceptible target cells and by secretion of immunoregulatory cytokines such as IFN-γ. Activation of these effector functions is triggered upon recognition of tumor and pathogen (mostly virus)-infected cel...

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Autores principales: Zwirner, Norberto Walter, Ziblat, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243847/
https://www.ncbi.nlm.nih.gov/pubmed/28154569
http://dx.doi.org/10.3389/fimmu.2017.00025
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author Zwirner, Norberto Walter
Ziblat, Andrea
author_facet Zwirner, Norberto Walter
Ziblat, Andrea
author_sort Zwirner, Norberto Walter
collection PubMed
description Natural killer (NK) cells are characterized by their ability to detect and induce apoptosis of susceptible target cells and by secretion of immunoregulatory cytokines such as IFN-γ. Activation of these effector functions is triggered upon recognition of tumor and pathogen (mostly virus)-infected cells and because of a bidirectional cross talk that NK cells establish with other cells of myeloid origin such as dendritic cells (DC) and macrophages. A common characteristic of these myeloid cells is their ability to secrete different members of the IL-12 family of cytokines such as IL-12, IL-23, and IL-27 and cytokines such as IL-15 and IL-18. Although the effect of IL-12, IL-15, and IL-18 has been characterized, the effect of IL-23 and IL-27 on NK cells (especially human) remains ill-defined. Particularly, IL-27 is a cytokine with dual functions as it has been described as pro- and as anti-inflammatory in different experimental settings. Recent evidence indicates that this cytokine indeed promotes human NK cell activation, IFN-γ secretion, NKp46-dependent NK cell-mediated cytotoxicity, and antibody (Ab)-dependent NK cell-mediated cytotoxicity (ADCC) against monoclonal Ab-coated tumor cells. Remarkably, IL-27 also primes NK cells for IL-18 responsiveness, enhancing these functional responses. Consequently, IL-27 acts as a pro-inflammatory cytokine that, in concert with other DC-derived cytokines, hierarchically contributes to NK cells activation and effector functions, which likely contributes to foster the adaptive immune response in different physiopathological conditions.
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spelling pubmed-52438472017-02-02 Regulation of NK Cell Activation and Effector Functions by the IL-12 Family of Cytokines: The Case of IL-27 Zwirner, Norberto Walter Ziblat, Andrea Front Immunol Immunology Natural killer (NK) cells are characterized by their ability to detect and induce apoptosis of susceptible target cells and by secretion of immunoregulatory cytokines such as IFN-γ. Activation of these effector functions is triggered upon recognition of tumor and pathogen (mostly virus)-infected cells and because of a bidirectional cross talk that NK cells establish with other cells of myeloid origin such as dendritic cells (DC) and macrophages. A common characteristic of these myeloid cells is their ability to secrete different members of the IL-12 family of cytokines such as IL-12, IL-23, and IL-27 and cytokines such as IL-15 and IL-18. Although the effect of IL-12, IL-15, and IL-18 has been characterized, the effect of IL-23 and IL-27 on NK cells (especially human) remains ill-defined. Particularly, IL-27 is a cytokine with dual functions as it has been described as pro- and as anti-inflammatory in different experimental settings. Recent evidence indicates that this cytokine indeed promotes human NK cell activation, IFN-γ secretion, NKp46-dependent NK cell-mediated cytotoxicity, and antibody (Ab)-dependent NK cell-mediated cytotoxicity (ADCC) against monoclonal Ab-coated tumor cells. Remarkably, IL-27 also primes NK cells for IL-18 responsiveness, enhancing these functional responses. Consequently, IL-27 acts as a pro-inflammatory cytokine that, in concert with other DC-derived cytokines, hierarchically contributes to NK cells activation and effector functions, which likely contributes to foster the adaptive immune response in different physiopathological conditions. Frontiers Media S.A. 2017-01-19 /pmc/articles/PMC5243847/ /pubmed/28154569 http://dx.doi.org/10.3389/fimmu.2017.00025 Text en Copyright © 2017 Zwirner and Ziblat. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zwirner, Norberto Walter
Ziblat, Andrea
Regulation of NK Cell Activation and Effector Functions by the IL-12 Family of Cytokines: The Case of IL-27
title Regulation of NK Cell Activation and Effector Functions by the IL-12 Family of Cytokines: The Case of IL-27
title_full Regulation of NK Cell Activation and Effector Functions by the IL-12 Family of Cytokines: The Case of IL-27
title_fullStr Regulation of NK Cell Activation and Effector Functions by the IL-12 Family of Cytokines: The Case of IL-27
title_full_unstemmed Regulation of NK Cell Activation and Effector Functions by the IL-12 Family of Cytokines: The Case of IL-27
title_short Regulation of NK Cell Activation and Effector Functions by the IL-12 Family of Cytokines: The Case of IL-27
title_sort regulation of nk cell activation and effector functions by the il-12 family of cytokines: the case of il-27
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243847/
https://www.ncbi.nlm.nih.gov/pubmed/28154569
http://dx.doi.org/10.3389/fimmu.2017.00025
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