Genetic Targeting in Cerebellar Purkinje Cells: an Update

Since the last review paper published in Cerebellum in 2002 [1], there has been a substantial increase in the number of experiments utilizing transgenic manipulations in murine cerebellar Purkinje cells. Most of these approaches were made possible with the use of the Cre/loxP methodology and pcp2/L7...

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Detalles Bibliográficos
Autores principales: Sługocka, Anna, Wiaderkiewicz, Jan, Barski, Jaroslaw J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243870/
https://www.ncbi.nlm.nih.gov/pubmed/26969183
http://dx.doi.org/10.1007/s12311-016-0770-4
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author Sługocka, Anna
Wiaderkiewicz, Jan
Barski, Jaroslaw J.
author_facet Sługocka, Anna
Wiaderkiewicz, Jan
Barski, Jaroslaw J.
author_sort Sługocka, Anna
collection PubMed
description Since the last review paper published in Cerebellum in 2002 [1], there has been a substantial increase in the number of experiments utilizing transgenic manipulations in murine cerebellar Purkinje cells. Most of these approaches were made possible with the use of the Cre/loxP methodology and pcp2/L7 based Cre recombinase expressing transgenic mouse strains. This review aims to summarize all studies which used Purkinje cell specific transgenesis since the first use of mouse strain with Purkinje cell specific Cre expression in 2002.
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spelling pubmed-52438702017-02-01 Genetic Targeting in Cerebellar Purkinje Cells: an Update Sługocka, Anna Wiaderkiewicz, Jan Barski, Jaroslaw J. Cerebellum Review Since the last review paper published in Cerebellum in 2002 [1], there has been a substantial increase in the number of experiments utilizing transgenic manipulations in murine cerebellar Purkinje cells. Most of these approaches were made possible with the use of the Cre/loxP methodology and pcp2/L7 based Cre recombinase expressing transgenic mouse strains. This review aims to summarize all studies which used Purkinje cell specific transgenesis since the first use of mouse strain with Purkinje cell specific Cre expression in 2002. Springer US 2016-03-11 2017 /pmc/articles/PMC5243870/ /pubmed/26969183 http://dx.doi.org/10.1007/s12311-016-0770-4 Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Sługocka, Anna
Wiaderkiewicz, Jan
Barski, Jaroslaw J.
Genetic Targeting in Cerebellar Purkinje Cells: an Update
title Genetic Targeting in Cerebellar Purkinje Cells: an Update
title_full Genetic Targeting in Cerebellar Purkinje Cells: an Update
title_fullStr Genetic Targeting in Cerebellar Purkinje Cells: an Update
title_full_unstemmed Genetic Targeting in Cerebellar Purkinje Cells: an Update
title_short Genetic Targeting in Cerebellar Purkinje Cells: an Update
title_sort genetic targeting in cerebellar purkinje cells: an update
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243870/
https://www.ncbi.nlm.nih.gov/pubmed/26969183
http://dx.doi.org/10.1007/s12311-016-0770-4
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