Atxn2 Knockout and CAG42-Knock-in Cerebellum Shows Similarly Dysregulated Expression in Calcium Homeostasis Pathway

Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominantly inherited neurodegenerative disorder with preferential affection of Purkinje neurons, which are known as integrators of calcium currents. The expansion of a polyglutamine (polyQ) domain in the RNA-binding protein ataxin-2 (ATXN2) is res...

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Detalles Bibliográficos
Autores principales: Halbach, Melanie Vanessa, Gispert, Suzana, Stehning, Tanja, Damrath, Ewa, Walter, Michael, Auburger, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243904/
https://www.ncbi.nlm.nih.gov/pubmed/26868665
http://dx.doi.org/10.1007/s12311-016-0762-4

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