Digital next-generation sequencing identifies low-abundance mutations in pancreatic juice samples collected from the duodenum of patients with pancreatic cancer and intraductal papillary mucinous neoplasms

OBJECTIVE: Secretin-stimulated pancreatic juice contains DNA shed from cells lining the pancreatic ducts. Genetic analysis of this fluid may form a test to detect pancreatic ductal neoplasia. DESIGN: We employed digital next-generation sequencing (‘digital NGS’) to detect low-abundance mutations in...

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Detalles Bibliográficos
Autores principales: Yu, Jun, Sadakari, Yoshihiko, Shindo, Koji, Suenaga, Masaya, Brant, Aaron, Almario, Jose Alejandro Navarro, Borges, Michael, Barkley, Thomas, Fesharakizadeh, Shahriar, Ford, Madeline, Hruban, Ralph H, Shin, Eun Ji, Lennon, Anne Marie, Canto, Marcia Irene, Goggins, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2017
Materias:
Pancreas
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243915/
https://www.ncbi.nlm.nih.gov/pubmed/27432539
http://dx.doi.org/10.1136/gutjnl-2015-311166

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