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Total synthesis and related studies of large, strained, and bioactive natural products
Our chemical syntheses and related scientific investigations of natural products with complex architectures and powerful biological activities are described, focusing on the very large 3 nm-long polycyclic ethers called the ciguatoxins, highly strained and labile chromoprotein antitumor antibiotics...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Japan Academy
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243947/ https://www.ncbi.nlm.nih.gov/pubmed/27725470 http://dx.doi.org/10.2183/pjab.92.290 |
| _version_ | 1782496605497196544 |
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| author | HIRAMA, Masahiro |
| author_facet | HIRAMA, Masahiro |
| author_sort | HIRAMA, Masahiro |
| collection | PubMed |
| description | Our chemical syntheses and related scientific investigations of natural products with complex architectures and powerful biological activities are described, focusing on the very large 3 nm-long polycyclic ethers called the ciguatoxins, highly strained and labile chromoprotein antitumor antibiotics featuring nine-membered enediyne cores, and extremely potent anthelmintic macrolides called the avermectins. |
| format | Online Article Text |
| id | pubmed-5243947 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | The Japan Academy |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-52439472017-02-21 Total synthesis and related studies of large, strained, and bioactive natural products HIRAMA, Masahiro Proc Jpn Acad Ser B Phys Biol Sci Review Our chemical syntheses and related scientific investigations of natural products with complex architectures and powerful biological activities are described, focusing on the very large 3 nm-long polycyclic ethers called the ciguatoxins, highly strained and labile chromoprotein antitumor antibiotics featuring nine-membered enediyne cores, and extremely potent anthelmintic macrolides called the avermectins. The Japan Academy 2016-10-11 /pmc/articles/PMC5243947/ /pubmed/27725470 http://dx.doi.org/10.2183/pjab.92.290 Text en © 2016 The Japan Academy This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Review HIRAMA, Masahiro Total synthesis and related studies of large, strained, and bioactive natural products |
| title | Total synthesis and related studies of large, strained, and bioactive natural products |
| title_full | Total synthesis and related studies of large, strained, and bioactive natural products |
| title_fullStr | Total synthesis and related studies of large, strained, and bioactive natural products |
| title_full_unstemmed | Total synthesis and related studies of large, strained, and bioactive natural products |
| title_short | Total synthesis and related studies of large, strained, and bioactive natural products |
| title_sort | total synthesis and related studies of large, strained, and bioactive natural products |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243947/ https://www.ncbi.nlm.nih.gov/pubmed/27725470 http://dx.doi.org/10.2183/pjab.92.290 |
| work_keys_str_mv | AT hiramamasahiro totalsynthesisandrelatedstudiesoflargestrainedandbioactivenaturalproducts |