Chelerythrine down regulates expression of VEGFA, BCL2 and KRAS by arresting G-Quadruplex structures at their promoter regions

A putative anticancer plant alkaloid, Chelerythrine binds to G-quadruplexes at promoters of VEGFA, BCL2 and KRAS genes and down regulates their expression. The association of Chelerythrine to G-quadruplex at the promoters of these oncogenes were monitored using UV absorption spectroscopy, fluorescen...

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Detalles Bibliográficos
Autores principales: Jana, Jagannath, Mondal, Soma, Bhattacharjee, Payel, Sengupta, Pallabi, Roychowdhury, Tanaya, Saha, Pranay, Kundu, Pallob, Chatterjee, Subhrangsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244364/
https://www.ncbi.nlm.nih.gov/pubmed/28102286
http://dx.doi.org/10.1038/srep40706

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