HO-1 inhibits preadipocyte proliferation and differentiation at the onset of obesity via ROS dependent activation of Akt2

Excessive accumulation of white adipose tissue (WAT) is a hallmark of obesity. The expansion of WAT in obesity involves proliferation and differentiation of adipose precursors, however, the underlying molecular mechanisms remain unclear. Here, we used an unbiased transcriptomics approach to identify...

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Detalles Bibliográficos
Autores principales: Wagner, Gabriel, Lindroos-Christensen, Josefine, Einwallner, Elisa, Husa, Julia, Zapf, Thea-Christin, Lipp, Katharina, Rauscher, Sabine, Gröger, Marion, Spittler, Andreas, Loewe, Robert, Gruber, Florian, Duvigneau, J. Catharina, Mohr, Thomas, Sutterlüty-Fall, Hedwig, Klinglmüller, Florian, Prager, Gerhard, Huppertz, Berthold, Yun, Jeanho, Wagner, Oswald, Esterbauer, Harald, Bilban, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244367/
https://www.ncbi.nlm.nih.gov/pubmed/28102348
http://dx.doi.org/10.1038/srep40881

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