WHSC1L1-mediated EGFR mono-methylation enhances the cytoplasmic and nuclear oncogenic activity of EGFR in head and neck cancer

While multiple post-translational modifications have been reported to regulate the function of epidermal growth factor receptor (EGFR), the effect of protein methylation on its function has not been well characterized. In this study, we show that WHSC1L1 mono-methylates lysine 721 in the tyrosine ki...

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Detalles Bibliográficos
Autores principales: Saloura, Vassiliki, Vougiouklakis, Theodore, Zewde, Makda, Deng, Xiaolan, Kiyotani, Kazuma, Park, Jae-Hyun, Matsuo, Yo, Lingen, Mark, Suzuki, Takehiro, Dohmae, Naoshi, Hamamoto, Ryuji, Nakamura, Yusuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244396/
https://www.ncbi.nlm.nih.gov/pubmed/28102297
http://dx.doi.org/10.1038/srep40664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244396/
https://www.ncbi.nlm.nih.gov/pubmed/28102297
http://dx.doi.org/10.1038/srep40664

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