Human p53 interacts with the elongating RNAPII complex and is required for the release of actinomycin D induced transcription blockage

The p53 tumour suppressor regulates the transcription initiation of selected genes by binding to specific DNA sequences at their promoters. Here we report a novel role of p53 in transcription elongation in human cells. Our data demonstrate that upon transcription elongation blockage, p53 is associat...

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Detalles Bibliográficos
Autores principales: Borsos, Barbara N., Huliák, Ildikó, Majoros, Hajnalka, Ujfaludi, Zsuzsanna, Gyenis, Ákos, Pukler, Peter, Boros, Imre M., Pankotai, Tibor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244413/
https://www.ncbi.nlm.nih.gov/pubmed/28102346
http://dx.doi.org/10.1038/srep40960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244413/
https://www.ncbi.nlm.nih.gov/pubmed/28102346
http://dx.doi.org/10.1038/srep40960

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