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Thermodynamic and kinetic stability of the Josephin Domain closed arrangement: evidences from replica exchange molecular dynamics

BACKGROUND: Molecular phenomena driving pathological aggregation in neurodegenerative diseases are not completely understood yet. Peculiar is the case of Spinocerebellar Ataxia 3 (SCA3) where the conformational properties of the AT-3 N-terminal region, also called Josephin Domain (JD), play a key ro...

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Detalles Bibliográficos
Autores principales:	Grasso, Gianvito, Tuszynski, Jack A., Morbiducci, Umberto, Licandro, Ginevra, Danani, Andrea, Deriu, Marco A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244572/ https://www.ncbi.nlm.nih.gov/pubmed/28103906 http://dx.doi.org/10.1186/s13062-016-0173-y

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