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Efficacy of olanzapine in symptom relief and quality of life in gastric cancer patients receiving chemotherapy
BACKGROUND: Considering the incidence and prevalence rates of gastric cancer in Mazandaran Province of Iran, this research was performed to evaluate the efficacy and safety of olanzapine in symptom relief and quality of life (QOL) improvement of gastric patients receiving chemotherapy. MATERIALS AND...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244650/ https://www.ncbi.nlm.nih.gov/pubmed/28163734 http://dx.doi.org/10.4103/1735-1995.192504 |
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author | Nikbakhsh, Novin Sadeghi, Mohsen Vakili Ramzani, Elham Moudi, Sussan Bijani, Ali Yousefi, Roya Moudi, Marjan Gholinia, Hemmat |
author_facet | Nikbakhsh, Novin Sadeghi, Mohsen Vakili Ramzani, Elham Moudi, Sussan Bijani, Ali Yousefi, Roya Moudi, Marjan Gholinia, Hemmat |
author_sort | Nikbakhsh, Novin |
collection | PubMed |
description | BACKGROUND: Considering the incidence and prevalence rates of gastric cancer in Mazandaran Province of Iran, this research was performed to evaluate the efficacy and safety of olanzapine in symptom relief and quality of life (QOL) improvement of gastric patients receiving chemotherapy. MATERIALS AND METHODS: This clinical trial was conducted on thirty new cases of gastric cancer patients whose treatment protocol was planned on chemotherapy and were allocated into two groups by simple random sampling. Intervention group (15 patients) received olanzapine tablets (2.5–10 mg/day) a day before the beginning of chemotherapy; in the 1(st) day of chemotherapy to 8 weeks after chemotherapy, besides the routine treatment regimens. The control group received only the routine treatment regimens. The patients were followed for 8 weeks after intervention. All of the patients were assessed with Hospital Anxiety and Depression Scale (HADS) and WHO-QOL-BREF questionnaires; further, Rhodes index was used to evaluate nausea and vomiting (N/V) status. RESULTS: All the recruited patients continued the allocated interventions (no lost to follow-up). N/V decreased in the case group, but the difference was not statistically significant (P = 0.438). The patients' appetite and body mass index increased (P = 0.006). Anxiety and depression subscales of HADS had significant differences between the two groups (P < 0.001) in the 4(th) and 8(th) week after treatment. Among the different subdomains of QOL, only physical health improved significantly after intervention (P < 0.05), but no significant difference was observed in other subdomains and also total QOL score (P > 0.05). No significant increase was observed in fasting and 2-h postprandial blood glucose and lipid profile (P > 0.05). CONCLUSION: Olanzapine can be considered as an effective drug to increase appetite and decrease anxiety and depression in patients with gastric cancer. |
format | Online Article Text |
id | pubmed-5244650 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-52446502017-02-03 Efficacy of olanzapine in symptom relief and quality of life in gastric cancer patients receiving chemotherapy Nikbakhsh, Novin Sadeghi, Mohsen Vakili Ramzani, Elham Moudi, Sussan Bijani, Ali Yousefi, Roya Moudi, Marjan Gholinia, Hemmat J Res Med Sci Original Article BACKGROUND: Considering the incidence and prevalence rates of gastric cancer in Mazandaran Province of Iran, this research was performed to evaluate the efficacy and safety of olanzapine in symptom relief and quality of life (QOL) improvement of gastric patients receiving chemotherapy. MATERIALS AND METHODS: This clinical trial was conducted on thirty new cases of gastric cancer patients whose treatment protocol was planned on chemotherapy and were allocated into two groups by simple random sampling. Intervention group (15 patients) received olanzapine tablets (2.5–10 mg/day) a day before the beginning of chemotherapy; in the 1(st) day of chemotherapy to 8 weeks after chemotherapy, besides the routine treatment regimens. The control group received only the routine treatment regimens. The patients were followed for 8 weeks after intervention. All of the patients were assessed with Hospital Anxiety and Depression Scale (HADS) and WHO-QOL-BREF questionnaires; further, Rhodes index was used to evaluate nausea and vomiting (N/V) status. RESULTS: All the recruited patients continued the allocated interventions (no lost to follow-up). N/V decreased in the case group, but the difference was not statistically significant (P = 0.438). The patients' appetite and body mass index increased (P = 0.006). Anxiety and depression subscales of HADS had significant differences between the two groups (P < 0.001) in the 4(th) and 8(th) week after treatment. Among the different subdomains of QOL, only physical health improved significantly after intervention (P < 0.05), but no significant difference was observed in other subdomains and also total QOL score (P > 0.05). No significant increase was observed in fasting and 2-h postprandial blood glucose and lipid profile (P > 0.05). CONCLUSION: Olanzapine can be considered as an effective drug to increase appetite and decrease anxiety and depression in patients with gastric cancer. Medknow Publications & Media Pvt Ltd 2016-10-18 /pmc/articles/PMC5244650/ /pubmed/28163734 http://dx.doi.org/10.4103/1735-1995.192504 Text en Copyright: © 2016 Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Nikbakhsh, Novin Sadeghi, Mohsen Vakili Ramzani, Elham Moudi, Sussan Bijani, Ali Yousefi, Roya Moudi, Marjan Gholinia, Hemmat Efficacy of olanzapine in symptom relief and quality of life in gastric cancer patients receiving chemotherapy |
title | Efficacy of olanzapine in symptom relief and quality of life in gastric cancer patients receiving chemotherapy |
title_full | Efficacy of olanzapine in symptom relief and quality of life in gastric cancer patients receiving chemotherapy |
title_fullStr | Efficacy of olanzapine in symptom relief and quality of life in gastric cancer patients receiving chemotherapy |
title_full_unstemmed | Efficacy of olanzapine in symptom relief and quality of life in gastric cancer patients receiving chemotherapy |
title_short | Efficacy of olanzapine in symptom relief and quality of life in gastric cancer patients receiving chemotherapy |
title_sort | efficacy of olanzapine in symptom relief and quality of life in gastric cancer patients receiving chemotherapy |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244650/ https://www.ncbi.nlm.nih.gov/pubmed/28163734 http://dx.doi.org/10.4103/1735-1995.192504 |
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