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Different but synergistic effects of bone marrow-derived VEGFR2(+) and VEGFR2(−)CD45(+) cells during hepatocellular carcinoma progression

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-associated mortality worldwide in men. Bone marrow-derived cells (BMDCs), including circulating endothelial progenitor cells, have been reported to be involved in the progression of HCC. The complexity of BMDCs inspires further int...

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Autores principales: Zhu, Xiaolin, Zhou, Hongyuan, Luo, Jingtao, Cui, Yunlong, Li, Huikai, Zhang, Wei, Fang, Feng, Li, Qiang, Zhang, Ti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244973/
https://www.ncbi.nlm.nih.gov/pubmed/28123523
http://dx.doi.org/10.3892/ol.2016.5411
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author Zhu, Xiaolin
Zhou, Hongyuan
Luo, Jingtao
Cui, Yunlong
Li, Huikai
Zhang, Wei
Fang, Feng
Li, Qiang
Zhang, Ti
author_facet Zhu, Xiaolin
Zhou, Hongyuan
Luo, Jingtao
Cui, Yunlong
Li, Huikai
Zhang, Wei
Fang, Feng
Li, Qiang
Zhang, Ti
author_sort Zhu, Xiaolin
collection PubMed
description Hepatocellular carcinoma (HCC) is the second leading cause of cancer-associated mortality worldwide in men. Bone marrow-derived cells (BMDCs), including circulating endothelial progenitor cells, have been reported to be involved in the progression of HCC. The complexity of BMDCs inspires further interest in the study of HCC. In the present study, highly metastatic HCC models with BM function deficiency/reconstruction were established by sublethal irradiation/BM transplantation. The effects of vascular endothelial growth factor receptor-2 (VEGFR2)(+) or VEGFR2(−)/cluster of differentiation 45 (CD45)(+) BMDCs on HCC growth were evaluated. VEGFR2(+) and VEGFR2(−)CD45(+) BMDCs facilitated the recovery of BM function and promoted tumor growth, while the enhancement of tumor growth by VEGFR2(−)CD45(+) BMDCs was independent of VEGFR2(+) BMDCs. BM-derived CD45(+)CD133(+) and VEGFR2(+)CD133(+) cells synergistically played a role in the different stages during HCC progression. In conclusion, different types of BMDCs exhibit effects on HCC tumor growth in a coordinated manner.
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spelling pubmed-52449732017-01-25 Different but synergistic effects of bone marrow-derived VEGFR2(+) and VEGFR2(−)CD45(+) cells during hepatocellular carcinoma progression Zhu, Xiaolin Zhou, Hongyuan Luo, Jingtao Cui, Yunlong Li, Huikai Zhang, Wei Fang, Feng Li, Qiang Zhang, Ti Oncol Lett Articles Hepatocellular carcinoma (HCC) is the second leading cause of cancer-associated mortality worldwide in men. Bone marrow-derived cells (BMDCs), including circulating endothelial progenitor cells, have been reported to be involved in the progression of HCC. The complexity of BMDCs inspires further interest in the study of HCC. In the present study, highly metastatic HCC models with BM function deficiency/reconstruction were established by sublethal irradiation/BM transplantation. The effects of vascular endothelial growth factor receptor-2 (VEGFR2)(+) or VEGFR2(−)/cluster of differentiation 45 (CD45)(+) BMDCs on HCC growth were evaluated. VEGFR2(+) and VEGFR2(−)CD45(+) BMDCs facilitated the recovery of BM function and promoted tumor growth, while the enhancement of tumor growth by VEGFR2(−)CD45(+) BMDCs was independent of VEGFR2(+) BMDCs. BM-derived CD45(+)CD133(+) and VEGFR2(+)CD133(+) cells synergistically played a role in the different stages during HCC progression. In conclusion, different types of BMDCs exhibit effects on HCC tumor growth in a coordinated manner. D.A. Spandidos 2017-01 2016-11-22 /pmc/articles/PMC5244973/ /pubmed/28123523 http://dx.doi.org/10.3892/ol.2016.5411 Text en Copyright: © Zhu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Zhu, Xiaolin
Zhou, Hongyuan
Luo, Jingtao
Cui, Yunlong
Li, Huikai
Zhang, Wei
Fang, Feng
Li, Qiang
Zhang, Ti
Different but synergistic effects of bone marrow-derived VEGFR2(+) and VEGFR2(−)CD45(+) cells during hepatocellular carcinoma progression
title Different but synergistic effects of bone marrow-derived VEGFR2(+) and VEGFR2(−)CD45(+) cells during hepatocellular carcinoma progression
title_full Different but synergistic effects of bone marrow-derived VEGFR2(+) and VEGFR2(−)CD45(+) cells during hepatocellular carcinoma progression
title_fullStr Different but synergistic effects of bone marrow-derived VEGFR2(+) and VEGFR2(−)CD45(+) cells during hepatocellular carcinoma progression
title_full_unstemmed Different but synergistic effects of bone marrow-derived VEGFR2(+) and VEGFR2(−)CD45(+) cells during hepatocellular carcinoma progression
title_short Different but synergistic effects of bone marrow-derived VEGFR2(+) and VEGFR2(−)CD45(+) cells during hepatocellular carcinoma progression
title_sort different but synergistic effects of bone marrow-derived vegfr2(+) and vegfr2(−)cd45(+) cells during hepatocellular carcinoma progression
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244973/
https://www.ncbi.nlm.nih.gov/pubmed/28123523
http://dx.doi.org/10.3892/ol.2016.5411
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