Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer

Drugs that inhibit estrogen receptor-α (ER) activity have been highly successful in treating and reducing breast cancer progression in ER-positive disease. However, resistance to these therapies presents a major clinical problem. Recent genetic studies have shown that mutations in the ER gene are fo...

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Detalles Bibliográficos
Autores principales: Harrod, A, Fulton, J, Nguyen, V T M, Periyasamy, M, Ramos-Garcia, L, Lai, C-F, Metodieva, G, de Giorgio, A, Williams, R L, Santos, D B, Gomez, P J, Lin, M-L, Metodiev, M V, Stebbing, J, Castellano, L, Magnani, L, Coombes, R C, Buluwela, L, Ali, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245767/
https://www.ncbi.nlm.nih.gov/pubmed/27748765
http://dx.doi.org/10.1038/onc.2016.382

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