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Lysosomal membrane protein SIDT2 mediates the direct uptake of DNA by lysosomes
Lysosomes degrade macromolecules such as proteins and nucleic acids. We previously identified 2 novel types of autophagy, RNautophagy and DNautophagy, where lysosomes directly take up RNA and DNA, in an ATP-dependent manner, for degradation. We have also reported that SIDT2 (SID1 transmembrane famil...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245770/ https://www.ncbi.nlm.nih.gov/pubmed/27846365 http://dx.doi.org/10.1080/15548627.2016.1248019 |
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author | Aizawa, Shu Contu, Viorica Raluca Fujiwara, Yuuki Hase, Katsunori Kikuchi, Hisae Kabuta, Chihana Wada, Keiji Kabuta, Tomohiro |
author_facet | Aizawa, Shu Contu, Viorica Raluca Fujiwara, Yuuki Hase, Katsunori Kikuchi, Hisae Kabuta, Chihana Wada, Keiji Kabuta, Tomohiro |
author_sort | Aizawa, Shu |
collection | PubMed |
description | Lysosomes degrade macromolecules such as proteins and nucleic acids. We previously identified 2 novel types of autophagy, RNautophagy and DNautophagy, where lysosomes directly take up RNA and DNA, in an ATP-dependent manner, for degradation. We have also reported that SIDT2 (SID1 transmembrane family, member 2), an ortholog of the Caenorhabditis elegans putative RNA transporter SID-1 (systemic RNA interference defective-1), mediates RNA translocation during RNautophagy. In this addendum, we report that SIDT2 also mediates DNA translocation in the process of DNautophagy. These findings help elucidate the mechanisms underlying the direct uptake of nucleic acids by lysosomes and the physiological functions of DNautophagy. |
format | Online Article Text |
id | pubmed-5245770 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-52457702017-01-25 Lysosomal membrane protein SIDT2 mediates the direct uptake of DNA by lysosomes Aizawa, Shu Contu, Viorica Raluca Fujiwara, Yuuki Hase, Katsunori Kikuchi, Hisae Kabuta, Chihana Wada, Keiji Kabuta, Tomohiro Autophagy Addendum Lysosomes degrade macromolecules such as proteins and nucleic acids. We previously identified 2 novel types of autophagy, RNautophagy and DNautophagy, where lysosomes directly take up RNA and DNA, in an ATP-dependent manner, for degradation. We have also reported that SIDT2 (SID1 transmembrane family, member 2), an ortholog of the Caenorhabditis elegans putative RNA transporter SID-1 (systemic RNA interference defective-1), mediates RNA translocation during RNautophagy. In this addendum, we report that SIDT2 also mediates DNA translocation in the process of DNautophagy. These findings help elucidate the mechanisms underlying the direct uptake of nucleic acids by lysosomes and the physiological functions of DNautophagy. Taylor & Francis 2016-11-15 /pmc/articles/PMC5245770/ /pubmed/27846365 http://dx.doi.org/10.1080/15548627.2016.1248019 Text en © 2017 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
spellingShingle | Addendum Aizawa, Shu Contu, Viorica Raluca Fujiwara, Yuuki Hase, Katsunori Kikuchi, Hisae Kabuta, Chihana Wada, Keiji Kabuta, Tomohiro Lysosomal membrane protein SIDT2 mediates the direct uptake of DNA by lysosomes |
title | Lysosomal membrane protein SIDT2 mediates the direct uptake of DNA by lysosomes |
title_full | Lysosomal membrane protein SIDT2 mediates the direct uptake of DNA by lysosomes |
title_fullStr | Lysosomal membrane protein SIDT2 mediates the direct uptake of DNA by lysosomes |
title_full_unstemmed | Lysosomal membrane protein SIDT2 mediates the direct uptake of DNA by lysosomes |
title_short | Lysosomal membrane protein SIDT2 mediates the direct uptake of DNA by lysosomes |
title_sort | lysosomal membrane protein sidt2 mediates the direct uptake of dna by lysosomes |
topic | Addendum |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245770/ https://www.ncbi.nlm.nih.gov/pubmed/27846365 http://dx.doi.org/10.1080/15548627.2016.1248019 |
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