Cargando…

Cranberry juice concentrate does not significantly decrease the incidence of acquired bacteriuria in female hip fracture patients receiving urine catheter: a double-blind randomized trial

BACKGROUND: Urinary tract infection (UTI) is a common complication among patients with hip fractures. Receiving an indwelling urinary catheter is a risk factor for developing UTIs. Treatment of symptomatic UTIs with antibiotics is expensive and can result in the development of antimicrobial resistan...

Descripción completa

Detalles Bibliográficos
Autores principales: Gunnarsson, Anna-Karin, Gunningberg, Lena, Larsson, Sune, Jonsson, Kenneth B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245868/
https://www.ncbi.nlm.nih.gov/pubmed/28144131
http://dx.doi.org/10.2147/CIA.S113597
_version_ 1782496897046413312
author Gunnarsson, Anna-Karin
Gunningberg, Lena
Larsson, Sune
Jonsson, Kenneth B
author_facet Gunnarsson, Anna-Karin
Gunningberg, Lena
Larsson, Sune
Jonsson, Kenneth B
author_sort Gunnarsson, Anna-Karin
collection PubMed
description BACKGROUND: Urinary tract infection (UTI) is a common complication among patients with hip fractures. Receiving an indwelling urinary catheter is a risk factor for developing UTIs. Treatment of symptomatic UTIs with antibiotics is expensive and can result in the development of antimicrobial resistance. Cranberries are thought to prevent UTI. There is no previous research on this potential effect in patients with hip fracture who receive urinary catheters. AIM: The aim of this study is to investigate whether intake of cranberry juice concentrate pre-operatively decreases the incidence of postoperative UTIs in hip fracture patients that received a urinary catheter. DESIGN: This study employed a randomized, placebo-controlled double-blind trial. METHOD: Female patients, aged 60 years and older, with hip fracture (n=227) were randomized to receive cranberry or placebo capsules daily, from admission, until 5 days postoperatively. Urine cultures were obtained at admission, 5 and 14 days postoperatively. In addition, Euro Qual five Dimensions assessments were performed and patients were screened for UTI symptoms. RESULT: In the intention-to-treat analysis, there was no difference between the groups in the proportion of patients with hospital-acquired postoperative positive urine cultures at any time point. When limiting the analysis to patients that ingested at least 80% of the prescribed capsules, 13 of 33 (39%) in the placebo group and 13 of 47 (28%) in the cranberry group (P=0.270) had a positive urine culture at 5 days postoperatively. However, this difference was not statistically significant (P=0.270). CONCLUSION: Cranberry concentrate does not seem to effectively prevent UTIs in female patients with hip fracture and indwelling urinary catheter.
format Online
Article
Text
id pubmed-5245868
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-52458682017-01-31 Cranberry juice concentrate does not significantly decrease the incidence of acquired bacteriuria in female hip fracture patients receiving urine catheter: a double-blind randomized trial Gunnarsson, Anna-Karin Gunningberg, Lena Larsson, Sune Jonsson, Kenneth B Clin Interv Aging Original Research BACKGROUND: Urinary tract infection (UTI) is a common complication among patients with hip fractures. Receiving an indwelling urinary catheter is a risk factor for developing UTIs. Treatment of symptomatic UTIs with antibiotics is expensive and can result in the development of antimicrobial resistance. Cranberries are thought to prevent UTI. There is no previous research on this potential effect in patients with hip fracture who receive urinary catheters. AIM: The aim of this study is to investigate whether intake of cranberry juice concentrate pre-operatively decreases the incidence of postoperative UTIs in hip fracture patients that received a urinary catheter. DESIGN: This study employed a randomized, placebo-controlled double-blind trial. METHOD: Female patients, aged 60 years and older, with hip fracture (n=227) were randomized to receive cranberry or placebo capsules daily, from admission, until 5 days postoperatively. Urine cultures were obtained at admission, 5 and 14 days postoperatively. In addition, Euro Qual five Dimensions assessments were performed and patients were screened for UTI symptoms. RESULT: In the intention-to-treat analysis, there was no difference between the groups in the proportion of patients with hospital-acquired postoperative positive urine cultures at any time point. When limiting the analysis to patients that ingested at least 80% of the prescribed capsules, 13 of 33 (39%) in the placebo group and 13 of 47 (28%) in the cranberry group (P=0.270) had a positive urine culture at 5 days postoperatively. However, this difference was not statistically significant (P=0.270). CONCLUSION: Cranberry concentrate does not seem to effectively prevent UTIs in female patients with hip fracture and indwelling urinary catheter. Dove Medical Press 2017-01-13 /pmc/articles/PMC5245868/ /pubmed/28144131 http://dx.doi.org/10.2147/CIA.S113597 Text en © 2017 Gunnarsson et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Gunnarsson, Anna-Karin
Gunningberg, Lena
Larsson, Sune
Jonsson, Kenneth B
Cranberry juice concentrate does not significantly decrease the incidence of acquired bacteriuria in female hip fracture patients receiving urine catheter: a double-blind randomized trial
title Cranberry juice concentrate does not significantly decrease the incidence of acquired bacteriuria in female hip fracture patients receiving urine catheter: a double-blind randomized trial
title_full Cranberry juice concentrate does not significantly decrease the incidence of acquired bacteriuria in female hip fracture patients receiving urine catheter: a double-blind randomized trial
title_fullStr Cranberry juice concentrate does not significantly decrease the incidence of acquired bacteriuria in female hip fracture patients receiving urine catheter: a double-blind randomized trial
title_full_unstemmed Cranberry juice concentrate does not significantly decrease the incidence of acquired bacteriuria in female hip fracture patients receiving urine catheter: a double-blind randomized trial
title_short Cranberry juice concentrate does not significantly decrease the incidence of acquired bacteriuria in female hip fracture patients receiving urine catheter: a double-blind randomized trial
title_sort cranberry juice concentrate does not significantly decrease the incidence of acquired bacteriuria in female hip fracture patients receiving urine catheter: a double-blind randomized trial
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245868/
https://www.ncbi.nlm.nih.gov/pubmed/28144131
http://dx.doi.org/10.2147/CIA.S113597
work_keys_str_mv AT gunnarssonannakarin cranberryjuiceconcentratedoesnotsignificantlydecreasetheincidenceofacquiredbacteriuriainfemalehipfracturepatientsreceivingurinecatheteradoubleblindrandomizedtrial
AT gunningberglena cranberryjuiceconcentratedoesnotsignificantlydecreasetheincidenceofacquiredbacteriuriainfemalehipfracturepatientsreceivingurinecatheteradoubleblindrandomizedtrial
AT larssonsune cranberryjuiceconcentratedoesnotsignificantlydecreasetheincidenceofacquiredbacteriuriainfemalehipfracturepatientsreceivingurinecatheteradoubleblindrandomizedtrial
AT jonssonkennethb cranberryjuiceconcentratedoesnotsignificantlydecreasetheincidenceofacquiredbacteriuriainfemalehipfracturepatientsreceivingurinecatheteradoubleblindrandomizedtrial